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http://hdl.handle.net/1843/56514
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DC Field | Value | Language |
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dc.creator | Juliana B.drummond | pt_BR |
dc.creator | Izabela Guimarães Barbosa | pt_BR |
dc.creator | Robert Dantzer | pt_BR |
dc.creator | Antonio l. Teixeira | pt_BR |
dc.date.accessioned | 2023-07-17T20:38:40Z | - |
dc.date.available | 2023-07-17T20:38:40Z | - |
dc.date.issued | 2018-05-04 | - |
dc.citation.volume | 73 | pt_BR |
dc.citation.issue | 2018 | pt_BR |
dc.citation.spage | 41 | pt_BR |
dc.citation.epage | 50 | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.bbi.2018.05.003 | pt_BR |
dc.identifier.issn | 08891591 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/1843/56514 | - |
dc.description.resumo | Introduction: The effects of acute hypoglycemia on markers of inflammation have been investigated, but the results have been heterogeneous.Objective: We aimed to perform a systematic review about the acute effects of insulin-induced hypoglycemia on inflammatory markers in patients with diabetes as well as non-diabetic subjects.Methods: A systematic search of the literature using the electronic databases MEDLINE and SCOPUS was con ducted through September 2017. Search terms included: “hypoglycemia”,“ insulin”, “cytokines”, and “inflammation”. We included original studies assessing peripheral inflammatory markers during insulin-induced hypoglycemia in humans.Results: Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. Acute hypoglycemia increases total leukocyte number and several pro-inflammatory markers.Elevation in pro-inflammatory markers in response to insulin-induced acute hypoglycemia appears to be of similar magnitude in non-diabetic subjects and in type-1 diabetic patients with intact awareness of hypogly cemia. Adrenaline rises in response to acute hypoglycemia correlates with the increase of pro-inflammatory markers. Conclusion: Acute hypoglycemia induces a pro-inflammatory state in both type-1 diabetic and non-diabetic subjects with no apparent significant difference between these two populations. Activation of the sympathetic nervous system is a likely mediator of these effects. | pt_BR |
dc.format.mimetype | pt_BR | |
dc.language | eng | pt_BR |
dc.publisher | Universidade Federal de Minas Gerais | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.department | MED - DEPARTAMENTO DE CLÍNICA MÉDICA | pt_BR |
dc.publisher.department | MED - DEPARTAMENTO DE SAÚDE MENTAL | pt_BR |
dc.publisher.initials | UFMG | pt_BR |
dc.relation.ispartof | Brain, Behavior, and Immunity | - |
dc.rights | Acesso Aberto | pt_BR |
dc.subject | Hypoglycemia | pt_BR |
dc.subject | Insulin | pt_BR |
dc.subject.other | Hipoglicemia | pt_BR |
dc.subject.other | Insulisina | pt_BR |
dc.title | The effect of insulin-induced hypoglycemia on inflammatory markers: a systematic review | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.url.externa | https://www.sciencedirect.com/science/article/pii/S0889159118301740?via%3Dihub | pt_BR |
Appears in Collections: | Artigo de Periódico |
Files in This Item:
File | Description | Size | Format | |
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The effect of insulin-induced hypoglycemia on inflammatory markers pdfa.pdf | 412.15 kB | Adobe PDF | View/Open |
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