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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56514
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dc.creatorJuliana B.drummondpt_BR
dc.creatorIzabela Guimarães Barbosapt_BR
dc.creatorRobert Dantzerpt_BR
dc.creatorAntonio l. Teixeirapt_BR
dc.date.accessioned2023-07-17T20:38:40Z-
dc.date.available2023-07-17T20:38:40Z-
dc.date.issued2018-05-04-
dc.citation.volume73pt_BR
dc.citation.issue2018pt_BR
dc.citation.spage41pt_BR
dc.citation.epage50pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.bbi.2018.05.003pt_BR
dc.identifier.issn08891591pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56514-
dc.description.resumoIntroduction: The effects of acute hypoglycemia on markers of inflammation have been investigated, but the results have been heterogeneous.Objective: We aimed to perform a systematic review about the acute effects of insulin-induced hypoglycemia on inflammatory markers in patients with diabetes as well as non-diabetic subjects.Methods: A systematic search of the literature using the electronic databases MEDLINE and SCOPUS was con ducted through September 2017. Search terms included: “hypoglycemia”,“ insulin”, “cytokines”, and “inflammation”. We included original studies assessing peripheral inflammatory markers during insulin-induced hypoglycemia in humans.Results: Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. Acute hypoglycemia increases total leukocyte number and several pro-inflammatory markers.Elevation in pro-inflammatory markers in response to insulin-induced acute hypoglycemia appears to be of similar magnitude in non-diabetic subjects and in type-1 diabetic patients with intact awareness of hypogly cemia. Adrenaline rises in response to acute hypoglycemia correlates with the increase of pro-inflammatory markers. Conclusion: Acute hypoglycemia induces a pro-inflammatory state in both type-1 diabetic and non-diabetic subjects with no apparent significant difference between these two populations. Activation of the sympathetic nervous system is a likely mediator of these effects.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrain, Behavior, and Immunity-
dc.rightsAcesso Abertopt_BR
dc.subjectHypoglycemiapt_BR
dc.subjectInsulinpt_BR
dc.subject.otherHipoglicemiapt_BR
dc.subject.otherInsulisinapt_BR
dc.titleThe effect of insulin-induced hypoglycemia on inflammatory markers: a systematic reviewpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0889159118301740?via%3Dihubpt_BR
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