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Tipo:	Artigo de Periódico
Título:	Further evidence of accelerated aging in bipolar disorder: focus on gdf-15
Autor(es):	Fangyang Izabela Guimarães Barbosa Erica l. Vieira Moises e. Bauer Natalia p. Rocha Antonio l. Teixeira
Resumo:	BACKGROUND: Bipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients and controls, and to evaluate whether they were associated with clinical parameters. METHODS: Forty-six patients with type I BD (23 in euthymia and 23 in mania) and 33 healthy controls were recruited for this study. Plasma levels of GDF-15 were measured by immunoassay. RESULTS: The levels of GDF-15 were significantly higher (p < 0.001) in patients with BD in comparison with controls. In patients, GDF-15 levels correlated with age (rho = 0.434; p = 0.003) and illness duration (rho = 0.502; p = 0.001). CONCLUSION: Our findings corroborate the view that BD is an illness associated with accelerated aging.
Assunto:	Transtorno Bipolar Fator 15 de Diferenciação de Crescimento Envelhecimento
Idioma:	eng
País:	Brasil
Editor:	Universidade Federal de Minas Gerais
Sigla da Instituição:	UFMG
Departamento:	MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE SAÚDE MENTAL
Tipo de Acesso:	Acesso Aberto
Identificador DOI:	https://doi.org/10.1515/tnsci-2018-0004
URI:	http://hdl.handle.net/1843/56522
Data do documento:	9-Mar-2018
metadata.dc.url.externa:	https://www.degruyter.com/document/doi/10.1515/tnsci-2018-0004/html
metadata.dc.relation.ispartof:	Translational Neuroscience
Aparece nas coleções:	Artigo de Periódico

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