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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56522
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dc.creatorFangyangpt_BR
dc.creatorIzabela Guimarães Barbosapt_BR
dc.creatorErica l. Vieirapt_BR
dc.creatorMoises e. Bauerpt_BR
dc.creatorNatalia p. Rochapt_BR
dc.creatorAntonio l. Teixeirapt_BR
dc.date.accessioned2023-07-17T20:55:50Z-
dc.date.available2023-07-17T20:55:50Z-
dc.date.issued2018-03-09-
dc.citation.volume9pt_BR
dc.citation.issue1pt_BR
dc.citation.spage17pt_BR
dc.citation.epage21pt_BR
dc.identifier.doihttps://doi.org/10.1515/tnsci-2018-0004pt_BR
dc.identifier.issn20816936pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56522-
dc.description.resumoBACKGROUND: Bipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients and controls, and to evaluate whether they were associated with clinical parameters. METHODS: Forty-six patients with type I BD (23 in euthymia and 23 in mania) and 33 healthy controls were recruited for this study. Plasma levels of GDF-15 were measured by immunoassay. RESULTS: The levels of GDF-15 were significantly higher (p < 0.001) in patients with BD in comparison with controls. In patients, GDF-15 levels correlated with age (rho = 0.434; p = 0.003) and illness duration (rho = 0.502; p = 0.001). CONCLUSION: Our findings corroborate the view that BD is an illness associated with accelerated aging.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofTranslational Neuroscience-
dc.rightsAcesso Abertopt_BR
dc.subjectBipolar disorderpt_BR
dc.subjectGrowth Differentiation Factor 15pt_BR
dc.subjectAgingpt_BR
dc.subject.otherTranstorno Bipolarpt_BR
dc.subject.otherFator 15 de Diferenciação de Crescimentopt_BR
dc.subject.otherEnvelhecimentopt_BR
dc.titleFurther evidence of accelerated aging in bipolar disorder: focus on gdf-15pt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.degruyter.com/document/doi/10.1515/tnsci-2018-0004/htmlpt_BR
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