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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56524
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dc.creatorSatyajitmohitept_BR
dc.creatorSalvina m. de Campos-carlipt_BR
dc.creatorNatalia p. Rochapt_BR
dc.creatorShiva Sharmapt_BR
dc.creatorAline s. Mirandapt_BR
dc.creatorIzabela Guimarães Barbosapt_BR
dc.creatorJoao v. Salgadopt_BR
dc.creatorAna Cristina Simoes-e-silvapt_BR
dc.creatorAntonio l. Teixeirapt_BR
dc.date.accessioned2023-07-17T21:13:52Z-
dc.date.available2023-07-17T21:13:52Z-
dc.date.issued2018-06-18-
dc.citation.volume202pt_BR
dc.citation.spage50pt_BR
dc.citation.epage54pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.schres.2018.06.023pt_BR
dc.identifier.issn09209964pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56524-
dc.description.resumoThis study aimed at evaluating changes in the renin-angiotensin system (RAS) in patients with schizophrenia in comparison with controls. Plasma levels of angiotensin-converting enzyme (ACE), ACE2, angiotensin (Ang)-(1–7) and Ang II were assessed in 25 patients with schizophrenia and 20 controls. Patients with schizophrenia presented decreased levels of ACE compared to controls [median (25th–75th percentiles) = 434.79 (341.15–524.02) vs. 508.49 (396.34–608.72); p b 0.05]. No significant differences were found regarding ACE2, Ang-(1–7) and Ang II levels. There were no associations between the measured molecules and clinical parame ters. Our results corroborate the hypothesis that the RAS is involved in the pathophysiology of schizophreniapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofSchizophrenia Research-
dc.rightsAcesso Restritopt_BR
dc.subjectSchizophreniapt_BR
dc.subjectCognitionpt_BR
dc.subjectRenin-angiotensin systempt_BR
dc.subjectAngiotensinpt_BR
dc.subjectAngiotensin-converting enzymept_BR
dc.subject.otherEsquizofreniapt_BR
dc.subject.otherCogniçãopt_BR
dc.subject.otherSistema Renina-Angiotensinapt_BR
dc.subject.otherAngiotensinaspt_BR
dc.subject.otherInibidores da Enzima Conversora de Angiotensinapt_BR
dc.titleLower circulating levels of angiotensin-converting enzyme (ace) in patients with schizophreniapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0920996418303566?via%3Dihubpt_BR
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