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http://hdl.handle.net/1843/56524| Type: | Artigo de Periódico |
| Title: | Lower circulating levels of angiotensin-converting enzyme (ace) in patients with schizophrenia |
| Authors: | Satyajitmohite Salvina m. de Campos-carli Natalia p. Rocha Shiva Sharma Aline s. Miranda Izabela Guimarães Barbosa Joao v. Salgado Ana Cristina Simoes-e-silva Antonio l. Teixeira |
| Abstract: | This study aimed at evaluating changes in the renin-angiotensin system (RAS) in patients with schizophrenia in comparison with controls. Plasma levels of angiotensin-converting enzyme (ACE), ACE2, angiotensin (Ang)-(1–7) and Ang II were assessed in 25 patients with schizophrenia and 20 controls. Patients with schizophrenia presented decreased levels of ACE compared to controls [median (25th–75th percentiles) = 434.79 (341.15–524.02) vs. 508.49 (396.34–608.72); p b 0.05]. No significant differences were found regarding ACE2, Ang-(1–7) and Ang II levels. There were no associations between the measured molecules and clinical parame ters. Our results corroborate the hypothesis that the RAS is involved in the pathophysiology of schizophrenia |
| Subject: | Esquizofrenia Cognição Sistema Renina-Angiotensina Angiotensinas Inibidores da Enzima Conversora de Angiotensina |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE FARMACOLOGIA ICB - DEPARTAMENTO DE MORFOLOGIA MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE PEDIATRIA MED - DEPARTAMENTO DE SAÚDE MENTAL |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.schres.2018.06.023 |
| URI: | http://hdl.handle.net/1843/56524 |
| Issue Date: | 18-Jun-2018 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0920996418303566?via%3Dihub |
| metadata.dc.relation.ispartof: | Schizophrenia Research |
| Appears in Collections: | Artigo de Periódico |
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