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Tipo:	Artigo de Periódico
Título:	Increased insulin sensitivity in individuals with neurofibromatosis type 1
Autor(es):	Aline Stangherlin Martins Ann Kristine Jansen Luiz Oswaldo Carneiro Rodrigues Camila Maria Matos Márcio Leandro Ribeiro de Souza Débora Marques Miranda Nilton Alves Resende
Resumo:	Objects: To compare insulin resistance (IR) and metabolic aspects of patients with neurofibromatosis type 1 (NF1) and individuals without the disease. Subjects and methods: Forty patients with NF1 were matched by sex, age, and body mass index (BMI) to 40 controls from the community. Blood samples were collected for biochemical assessment. Homeostasis model assessment adiponectin (HOMA-AD), Homeostasis model assessment insulin resistance (HOMA-IR), and adiponectin/leptin ratio (ALR) were used to identify IR. Results: The median HOMA-IR values were similar between the groups. However, the HOMA-AD value was significantly lower and the ALR significantly higher in the NF1 group. Fasting blood glucose (FBG), leptin, and visfatin levels of patients with NF1 were significantly lower, although adiponectin levels were significantly higher than those in the controls. Fasting insulin and blood glucose levels 2 hours after administration of 75 g of dextrose, glycated hemoglobin, and resistin showed no significant differences between groups. The HOMA-AD correlated with BMI, FBG, blood glucose levels 2 hours after administration of 75 g of dextrose, fasting insulin, glycated hemoglobin, adiponectin, leptin, visfatin, ALR, and HOMA-IR. The ALR correlated with BMI leptin, visfatin, and adiponectin. Conclusions: Lower levels of FBG, leptin, visfatin, and HOMA-AD, and higher adiponectin levels and ALR may be related to increased insulin sensitivity and lower occurrence of type 2 diabetes mellitus in patients with NF1
Assunto:	Nutrição Neurofibromatoses Glicemia Diabetes mellitus Insulin resistance
Idioma:	eng
País:	Brasil
Editor:	Universidade Federal de Minas Gerais
Sigla da Instituição:	UFMG
Departamento:	ENF - DEPARTAMENTO DE ENFERMAGEM APLICADA ENF - DEPARTAMENTO DE NUTRIÇÃO
Tipo de Acesso:	Acesso Aberto
Identificador DOI:	https://doi.org/10.20945/2359-3997000000007
URI:	http://hdl.handle.net/1843/56634
Data do documento:	2018
metadata.dc.url.externa:	https://www.scielo.br/j/aem/a/pnCr3WjWc6PZTQ4P3zMvmMH/?lang=en
metadata.dc.relation.ispartof:	Archives of Endocrinology and Metabolism
Aparece nas coleções:	Artigo de Periódico

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