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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56634
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dc.creatorAline Stangherlin Martinspt_BR
dc.creatorAnn Kristine Jansenpt_BR
dc.creatorLuiz Oswaldo Carneiro Rodriguespt_BR
dc.creatorCamila Maria Matospt_BR
dc.creatorMárcio Leandro Ribeiro de Souzapt_BR
dc.creatorDébora Marques Mirandapt_BR
dc.creatorNilton Alves Resendept_BR
dc.date.accessioned2023-07-18T20:20:20Z-
dc.date.available2023-07-18T20:20:20Z-
dc.date.issued2018-
dc.citation.volume62pt_BR
dc.citation.issue1pt_BR
dc.citation.spage34pt_BR
dc.citation.epage39pt_BR
dc.identifier.doihttps://doi.org/10.20945/2359-3997000000007pt_BR
dc.identifier.issn2359-4292pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56634-
dc.description.resumoObjects: To compare insulin resistance (IR) and metabolic aspects of patients with neurofibromatosis type 1 (NF1) and individuals without the disease. Subjects and methods: Forty patients with NF1 were matched by sex, age, and body mass index (BMI) to 40 controls from the community. Blood samples were collected for biochemical assessment. Homeostasis model assessment adiponectin (HOMA-AD), Homeostasis model assessment insulin resistance (HOMA-IR), and adiponectin/leptin ratio (ALR) were used to identify IR. Results: The median HOMA-IR values were similar between the groups. However, the HOMA-AD value was significantly lower and the ALR significantly higher in the NF1 group. Fasting blood glucose (FBG), leptin, and visfatin levels of patients with NF1 were significantly lower, although adiponectin levels were significantly higher than those in the controls. Fasting insulin and blood glucose levels 2 hours after administration of 75 g of dextrose, glycated hemoglobin, and resistin showed no significant differences between groups. The HOMA-AD correlated with BMI, FBG, blood glucose levels 2 hours after administration of 75 g of dextrose, fasting insulin, glycated hemoglobin, adiponectin, leptin, visfatin, ALR, and HOMA-IR. The ALR correlated with BMI leptin, visfatin, and adiponectin. Conclusions: Lower levels of FBG, leptin, visfatin, and HOMA-AD, and higher adiponectin levels and ALR may be related to increased insulin sensitivity and lower occurrence of type 2 diabetes mellitus in patients with NF1pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENF - DEPARTAMENTO DE ENFERMAGEM APLICADApt_BR
dc.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃOpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofArchives of Endocrinology and Metabolismpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectNeurofibromatosis type 1pt_BR
dc.subjectBlood glucosept_BR
dc.subjectDiabetes mellituspt_BR
dc.subjectInsulin resistancept_BR
dc.subject.otherNutriçãopt_BR
dc.subject.otherNeurofibromatosespt_BR
dc.subject.otherGlicemiapt_BR
dc.subject.otherDiabetes mellituspt_BR
dc.subject.otherInsulin resistancept_BR
dc.titleIncreased insulin sensitivity in individuals with neurofibromatosis type 1pt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/aem/a/pnCr3WjWc6PZTQ4P3zMvmMH/?lang=enpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7081-8401pt_BR
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