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3. Artigo de Periódico

Type:	Artigo de Periódico
Title:	Non-alcoholic fatty liver disease in premenopausal women with polycystic ovary syndrome: a systematic review and meta-analysis
Authors:	Ana Luiza Lunardi Rocha L. C. Faria T. C. M. Guimarães Giovanna Vieira Moreira A. L. Cândido C. A. Couto Fernando Marcos dos Reis
Abstract:	Purpose Non-alcoholic fatty liver disease (NAFLD) is an insidious pathologic condition that can manifest from simple steatosis to steatohepatitis (NASH) with potential progression to cirrhosis. Like the polycystic ovary syndrome (PCOS), NAFLD is associated with obesity, diabetes mellitus, insulin resistance and metabolic syndrome. PCOS women have an increased risk of NAFLD, but it is debatable which features of PCOS, either specific (androgen excess) or unspecific (metabolic derangements) affect the NAFLD risk. Methods We performed a systematic review and meta-analysis of studies that addressed the association of PCOS and NAFLD. We selected 17 studies published between 2007 and 2017 that included 2734 PCOS patients and 2561 controls of similar age and body mass index (BMI). Results PCOS patients have increased prevalence of NAFLD (odds ratio 2.54, 95% confidence interval 2.19–2.95). PCOS women with hyperandrogenism (classic phenotype) have a higher prevalence of NAFLD compared to women with PCOS without hyperandrogenism, even after correction for confounding variables. Among women with PCOS, those with NAFLD have higher serum total testosterone (mean difference 0.40 nmol/L, 95% CI 0.29–0.50 nmol/L) and free androgen index (mean difference 4.46, 95% CI 3.53–5.39) than those without NAFLD. The studies that used multivariate analysis controlling for age, BMI, triglycerides, and insulin resistance index confirmed that serum androgens are independent predictors of NAFLD in women with PCOS. Conclusion The prevalence of NAFLD is increased in women with PCOS and the presence of NAFLD is associated with high serum androgen levels, in addition to obesity and insulin resistance.
Subject:	Obesidade Diabetes Resistência à insulina Síndrome metabólica
language:	por
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	https://doi.org/10.1007/s40618-017-0708-9
URI:	http://hdl.handle.net/1843/56740
Issue Date:	2017
metadata.dc.url.externa:	https://link.springer.com/article/10.1007/s40618-017-0708-9
metadata.dc.relation.ispartof:	Journal of Endocrinological Investigation
Appears in Collections:	Artigo de Periódico

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