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http://hdl.handle.net/1843/56768| Type: | Artigo de Periódico |
| Title: | Atorvastatin reduced soluble receptors of TNF-alpha in systemic lupus erythematosus |
| Authors: | Gilda Aparecida Ferreira A. L. Teixeira Débora Cerqueira Calderaro Emília Inoue Sato |
| Abstract: | The aim of this study was to evaluate the efficacy of atorvastatin to reduce the plasma levels of TNF system molecules(TNF-α, sTNFR1 and sTNFR2) and to assess their association with risk factors for accelerate atherosclerosis and clinical disease activity scores in SLE patients.In a previous study, 64 female SLE patients received 20 mg/day of atorvastatin and 24 SLE patients (non-treated group)were followed for 8 weeks. Plasma levels of TNF-α, sTNFR 1 and sTNFR 2 were measured by ELISA, at baseline and atthe end of the study.The plasma levels of sTNFR1 and sTNFR 2 showed a positive correlation with SLEDAI score. We also found a positivecorrelation between TNF-α and sTNFR 1 levels and SLICC score. Patients with current nephritis and patients with anti-dsDNA antibodies presented higher sTNFR1 and sTNFR2 levels. Patients with abdominal obesity and arterial hypertension also had higher plasma levels of soluble receptors. At the end of 8 weeks, we observed a significant decrease in sTNFR1 plasma levels in patients receiving atorvastatin [median (percentile), 876.5 (717–1284 pg/ml) vs. 748 (629.6–917.3 pg/ml),p=0.03], without difference regarding TNF-α and sTNFR2 plasma levels. The SLEDAI and SLICC scores were independent determinants of the plasma levels of sRTNF1.Atorvastatin reduced soluble receptors of TNF-α. The plasma levels of TNF-α, sTNFR1 and sTNFR2 may play a role in SLE activity and atherosclerosis, and might be evaluated as targets for new therapies. |
| Subject: | Lúpus Eritematoso Sistêmico Aterosclerose Atorvastatina |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | MED - DEPARTAMENTO DE APARELHO LOCOMOTOR MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
| Rights: | Acesso Aberto |
| URI: | http://hdl.handle.net/1843/56768 |
| Issue Date: | 2016 |
| metadata.dc.url.externa: | https://www.clinexprheumatol.org/abstract.asp?a=9060 |
| metadata.dc.relation.ispartof: | Clinical and Experimental Rheumatology |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Atorvastatin reduced soluble receptors of TNF-alpha in pdfa.pdf | 212.96 kB | Adobe PDF | View/Open |
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