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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56821
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dc.creatorSantuza Maria Souzamendonçapt_BR
dc.creatorTarcília Aparecida da Silvapt_BR
dc.creatorJôice Dias Corrêapt_BR
dc.creatorAlessandra Figueiredo de Souzapt_BR
dc.creatorDenise v. Travassospt_BR
dc.creatorDébora Cerqueira Calderaropt_BR
dc.creatorÉrica Leandro Marciano Vieirapt_BR
dc.creatorAntônio Lúcio Teixeirapt_BR
dc.creatorGilda Aparecida Ferreirapt_BR
dc.creatorNatália Pessoa Rochapt_BR
dc.date.accessioned2023-07-20T21:39:56Z-
dc.date.available2023-07-20T21:39:56Z-
dc.date.issued2018-05-14-
dc.citation.volume37pt_BR
dc.citation.spage208pt_BR
dc.citation.epage214pt_BR
dc.identifier.issn0392856Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56821-
dc.description.resumoThe immune system has an important role in the development of systemic lupus erythematosus (SLE) and chronic periodontitis (CP). Altered cytokines levels characterise both diseases and contributes to periodontal tissue damage in CP and to macrocomplexes deposition with connective tissue destruction in SLE. This study aimed to evaluate the production of salivary cytokines in patients with SLE and its association with periodontal status. The sample comprised 70 SLE patients and 70 paired controls. SLE activity and damage were scored using Systemic Lupus Erythematosus Disease Activity Index 2000 and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index. Subjects were classified as without or with CP. Salivary concentrations of IL-33, MMP2/TIMP2, RANK and OPG were measured by ELISA, while IL-2, IFNγ, TNFα, IL-4, IL-6, IL-10 and IL-17A were determined by Cytometric Bead Array. Linear regression models analysed association among SLE, CP and salivary cytokines.IL-6 and IL-17A concentrations were significantly higher in SLE/CP patients than controls/CP. Concentrations of IL-6, IL-17A and IL-33 were increased in SLE/CP individuals when compared to SLE without CP. Multivariate model revealed association of cumulative dose of corticoids with periodontal damage and of IL-33 salivary concentration with SLE activity.Our findings suggest that long-term therapy with corticoids would contribute with periodontal destruction in SLE patients. Moreover, the increased levels of IL-6, IL-17A and IL-33 in saliva of SLE subjects with CP may signal it as possible inflammatory pathways in this process.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE APARELHO LOCOMOTORpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofClinical and Experimental Rheumatology-
dc.rightsAcesso Abertopt_BR
dc.subjectsystemic lupus erythematosuspt_BR
dc.subjectChronic periodontitispt_BR
dc.subjectCytokinept_BR
dc.subjectSalivapt_BR
dc.subject.otherLúpus Eritematoso Sistêmicopt_BR
dc.subject.otherPeriodontite Crônicapt_BR
dc.subject.otherCitocinaspt_BR
dc.subject.otherSalivapt_BR
dc.titleImmunological signatures in saliva of systemic lupus erythematosus patients: influence of periodontal conditionpt_BR
dc.typeArtigo de Periódicopt_BR
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