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Type:	Artigo de Periódico
Title:	Immunological signatures in saliva of systemic lupus erythematosus patients: influence of periodontal condition
Authors:	Santuza Maria Souzamendonça Tarcília Aparecida da Silva Jôice Dias Corrêa Alessandra Figueiredo de Souza Denise v. Travassos Débora Cerqueira Calderaro Érica Leandro Marciano Vieira Antônio Lúcio Teixeira Gilda Aparecida Ferreira Natália Pessoa Rocha
Abstract:	The immune system has an important role in the development of systemic lupus erythematosus (SLE) and chronic periodontitis (CP). Altered cytokines levels characterise both diseases and contributes to periodontal tissue damage in CP and to macrocomplexes deposition with connective tissue destruction in SLE. This study aimed to evaluate the production of salivary cytokines in patients with SLE and its association with periodontal status. The sample comprised 70 SLE patients and 70 paired controls. SLE activity and damage were scored using Systemic Lupus Erythematosus Disease Activity Index 2000 and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index. Subjects were classified as without or with CP. Salivary concentrations of IL-33, MMP2/TIMP2, RANK and OPG were measured by ELISA, while IL-2, IFNγ, TNFα, IL-4, IL-6, IL-10 and IL-17A were determined by Cytometric Bead Array. Linear regression models analysed association among SLE, CP and salivary cytokines.IL-6 and IL-17A concentrations were significantly higher in SLE/CP patients than controls/CP. Concentrations of IL-6, IL-17A and IL-33 were increased in SLE/CP individuals when compared to SLE without CP. Multivariate model revealed association of cumulative dose of corticoids with periodontal damage and of IL-33 salivary concentration with SLE activity.Our findings suggest that long-term therapy with corticoids would contribute with periodontal destruction in SLE patients. Moreover, the increased levels of IL-6, IL-17A and IL-33 in saliva of SLE subjects with CP may signal it as possible inflammatory pathways in this process.
Subject:	Lúpus Eritematoso Sistêmico Periodontite Crônica Citocinas Saliva
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	MED - DEPARTAMENTO DE APARELHO LOCOMOTOR MED - DEPARTAMENTO DE CLÍNICA MÉDICA
Rights:	Acesso Aberto
URI:	http://hdl.handle.net/1843/56821
Issue Date:	14-May-2018
metadata.dc.relation.ispartof:	Clinical and Experimental Rheumatology
Appears in Collections:	Artigo de Periódico

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