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Type:	Artigo de Periódico
Title:	Age-related changes in bone architecture
Authors:	Vincenzo Giordano José Sérgio Franco Hilton Augusto Koch Pedro José Labronici Robinson Esteves Santos Pires Ney Pecegueiro do Amaral
Abstract:	Objective: to evaluate the histologic and morphometric characteristics of bone biopsies of the anterior iliac crest of patients of different age groups. Methods: we studied 30 bone samples from the iliac crest, using brightfield optical microscopy. We divided the samples by donors’ age groups in three groups: Group 1 (n = 10), subjects aged between 25 and 39 years; Group 2 (n = 10), subjects aged between 40 and 64 years; Group 3 (n = 10), individuals aged 65 years and over. We randomly divided the samples into two sets with 15 specimens. In the first study segment (n = 15), we used histological to assess the osteogenic property of the graft, through the analysis of cell reserve in the periosteum, the number of osteocytes in the lacunae and the number of Haversian and Volkmann’s canals. In the second study segment (n = 15), we investigated the morphology of osteoconductive property of the graft, through quantification of the trabecular meshwork (Vv) and trabecular area (Sv). Results: histologically, we observed degeneration of bone occurring with age, characterized by thinning of the periosteum, with gradual replacement of the steogenic layer by fibrous tissue, small amount of Haversian and Volkmann’s canals, osteocyte lacunae voids and fine spongy bone trabeculae, allowing ample medullary space, usually occupied by fat cells and adipocytes. Morphologically, with respect to the quantification of the trabecular meshwork (Vv), we found statistically significant differences between Groups 1 and 3 and between Groups 2 and 3, with reduction of the trabecular meshwork of about 45% in the elderly over 65 years old ; there was no statistically significant difference between Groups 1 and 2. There was also no statistical difference between the Groups regarding Sv. Conclusion: the results of this experiment suggest that, in the elderly (over 65 years old), the osteogenic property of autologous bone graft decreases and the osteoconductive property is compromised.
Subject:	Desenvolvimento Ósseo Biopsia Transplante Ósseo
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	MED - DEPARTAMENTO DE APARELHO LOCOMOTOR
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1590/0100-69912016004010
URI:	http://hdl.handle.net/1843/56928
Issue Date:	2016
metadata.dc.url.externa:	https://www.scielo.br/j/rcbc/a/dNFJDmVFntGXM8B5TqRTMmc/
metadata.dc.relation.ispartof:	Revista do Colégio Brasileiro de Cirurgiões
Appears in Collections:	Artigo de Periódico

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