Lack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease)

Debora Miranda; Patriciapereira; Antônio Marcos Alvim Soares Júnior; Maria Bicalho; Edgar de Moraes; Leandro Malloy-diniz; Jonas de Paula; Marco Romano-silva

Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/57104

Tipo:	Artigo de Periódico
Título:	Lack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease)
Autor(es):	Debora Miranda Patriciapereira Antônio Marcos Alvim Soares Júnior Maria Bicalho Edgar de Moraes Leandro Malloy-diniz Jonas de Paula Marco Romano-silva
Resumo:	Abstract: Objectives: This study aims to evaluate the association between polymorphisms in circadian genes and Alzheimer’s disease (AD) and/or late-onset de pression (LOD). AD pathology leads to circadian disturbances, with clear negative influence on quality of life. In addition, there is an increasing evidence that regulators of circadian system have effects on AD and LOD pathology. Design and Subjects: An exploratory case-control study designed to evaluate SNPs in the PER2, PER3, CLOCK and OX2R genes in a sample composed by 249 AD, 222 LOD and 112 healthy individuals. Measures: The participants were evaluated using DSM-IV criteria for LOD and NINCDS-ADRDA for AD. Results: In allelic analysis, the OX2R SNP, rs2134294, showed an association of allele C with LOD (p =0.02, OR= 1.6) and AD (p=0.04, OR =1.5). The rs2134294 also showed a genotypic association C/C (p =0.01) for higher risk to develop LOD compared to the control group, with an odd’s ratio of 2.7. The rs9370399 (OX2R) has also shown an association between A allele (p=0.03, OR= 1.4) and AD. These results do not persist after a 1,000 permutations test. For other markers of the OX2R gene and for all other markers of this study no association was found. Conclusion: In conclusion, the present study found that the investigated Circadian Genes (PER2, PER3, CLOCK and OX2R) polymorphisms were not associated with LOD or AD.
Assunto:	Polimorfismo de Nucleotídeo Único Doença de Alzheimer Homologia de Sequência Proteínas CLOCK Receptores de Orexina
Idioma:	eng
País:	Brasil
Editor:	Universidade Federal de Minas Gerais
Sigla da Instituição:	UFMG
Departamento:	FAF - DEPARTAMENTO DE PSICOLOGIA MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE PEDIATRIA MED - DEPARTAMENTO DE SAÚDE MENTAL
Tipo de Acesso:	Acesso Restrito
Identificador DOI:	10.2174/1567205013666160603005630
URI:	http://hdl.handle.net/1843/57104
Data do documento:	27-Abr-2016
metadata.dc.url.externa:	https://www.ingentaconnect.com/contentone/ben/car/2016/00000013/00000012/art00011
metadata.dc.relation.ispartof:	Current Alzheimer Research
Aparece nas coleções:	Artigo de Periódico

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