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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/57104
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dc.creatorDebora Mirandapt_BR
dc.creatorPatriciapereirapt_BR
dc.creatorAntônio Marcos Alvim Soares Júniorpt_BR
dc.creatorMaria Bicalhopt_BR
dc.creatorEdgar de Moraespt_BR
dc.creatorLeandro Malloy-dinizpt_BR
dc.creatorJonas de Paulapt_BR
dc.creatorMarco Romano-silvapt_BR
dc.date.accessioned2023-07-27T21:34:43Z-
dc.date.available2023-07-27T21:34:43Z-
dc.date.issued2016-04-27-
dc.citation.volume13pt_BR
dc.citation.issue999pt_BR
dc.citation.spage1pt_BR
dc.citation.epage1pt_BR
dc.identifier.doi10.2174/1567205013666160603005630pt_BR
dc.identifier.issn15672050pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/57104-
dc.description.resumoAbstract: Objectives: This study aims to evaluate the association between polymorphisms in circadian genes and Alzheimer’s disease (AD) and/or late-onset de pression (LOD). AD pathology leads to circadian disturbances, with clear negative influence on quality of life. In addition, there is an increasing evidence that regulators of circadian system have effects on AD and LOD pathology. Design and Subjects: An exploratory case-control study designed to evaluate SNPs in the PER2, PER3, CLOCK and OX2R genes in a sample composed by 249 AD, 222 LOD and 112 healthy individuals. Measures: The participants were evaluated using DSM-IV criteria for LOD and NINCDS-ADRDA for AD. Results: In allelic analysis, the OX2R SNP, rs2134294, showed an association of allele C with LOD (p =0.02, OR= 1.6) and AD (p=0.04, OR =1.5). The rs2134294 also showed a genotypic association C/C (p =0.01) for higher risk to develop LOD compared to the control group, with an odd’s ratio of 2.7. The rs9370399 (OX2R) has also shown an association between A allele (p=0.03, OR= 1.4) and AD. These results do not persist after a 1,000 permutations test. For other markers of the OX2R gene and for all other markers of this study no association was found. Conclusion: In conclusion, the present study found that the investigated Circadian Genes (PER2, PER3, CLOCK and OX2R) polymorphisms were not associated with LOD or AD.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAF - DEPARTAMENTO DE PSICOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofCurrent Alzheimer Research-
dc.rightsAcesso Restritopt_BR
dc.subjectSingle-nucleotide polymorphismpt_BR
dc.subjectLate-onset depressionpt_BR
dc.subjectAlzheimer’s Diseasept_BR
dc.subjectPeriod Homologpt_BR
dc.subjectCLOCKpt_BR
dc.subjectOrexin Receptor 2pt_BR
dc.subject.otherPolimorfismo de Nucleotídeo Únicopt_BR
dc.subject.otherDoença de Alzheimerpt_BR
dc.subject.otherHomologia de Sequênciapt_BR
dc.subject.otherProteínas CLOCKpt_BR
dc.subject.otherReceptores de Orexinapt_BR
dc.titleLack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease)pt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.ingentaconnect.com/contentone/ben/car/2016/00000013/00000012/art00011pt_BR
dc.identifier.orcid0000-0002-9649-867Xpt_BR
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