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http://hdl.handle.net/1843/57196| Type: | Artigo de Periódico |
| Title: | An esculetin-cobalt(III) archetype for redox-activated drug delivery platforms with hypoxic selectivity |
| Authors: | Renata Crispim Batista Carlos Basílio Pinheiro Fabio da Silva Miranda Mauricio Lanznaster |
| Abstract: | The motivation of this work was to probe whether coordination of esculetin to cobalt(III) could lead to a complex with the required properties to function as a redox-activated drug delivery platform, selective for hypoxic environments. The complex [Co(esc)(py2en)]ClO4·(CH3OH)2 (1) was obtained and fully characterized by CHN elemental analysis, single-crystal X-ray diffractometry, UV/Vis and fluorescence spectroscopy, and ESI mass spectrometry. The redox behavior of 1 was evaluated by cyclic and square wave voltammetry analyses in MeCN and PBS buffer, which revealed distinct potentials for the Co3+/Co2+ processes in aqueous and organic solutions. In PBS, the potential is within the accepted ideal range (–0.2 to –0.4 V vs. SHE) for reduction in biological systems. Thus, a selective release of the coumarin ligand in a hypoxic environment upon reduction was simulated by investigating reactions of 1 with sodium dithionite in argon-, air-, and O2-saturated atmospheres. An [O2]-dependent dissociation of esculetin was monitored over a 72 h period at 25 °C by UV/Vis spectroscopy and confirmed by fluorescence spectroscopy and ESI-MS data. These results provide strong evidence of a hypoxia-selective, redox-activated mechanism for the release of esculetin from this cobalt(III) complex. |
| Subject: | Cobalto |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE FÍSICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1002/ejic.201701251 |
| URI: | http://hdl.handle.net/1843/57196 |
| Issue Date: | 2018 |
| metadata.dc.url.externa: | https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejic.201701251 |
| metadata.dc.relation.ispartof: | European Journal of Inorganic Chemistry |
| Appears in Collections: | Artigo de Periódico |
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