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http://hdl.handle.net/1843/57269| Type: | Artigo de Periódico |
| Title: | Traumatic brain injury biomarkers in pediatric patients: a systematic review |
| Authors: | Antônio Lúcio Teixeira Ana Cristina Simões e Silva Lucas Alexandre Santos Marzano Aline Silva de Miranda Joao Pedro Thimotheo Batista Marina de Abreu Arruda Maíra Glória de Freitas Cardoso João Luís Vieira Monteiro de Barros Janaína Matos Moreira Priscila Menezes Ferri Liu |
| Abstract: | Traumatic brain injury (TBI) is the main cause of pediatric trauma death and disability worldwide. Recent studies have sought to identify biomarkers of TBI for the purpose of assessing functional outcomes. The aim of this systematic review was to evaluate the utility of TBI biomarkers in the pediatric population by summarizing recent fndings in the medical literature. A total of 303 articles were retrieved from our search. An initial screening to remove duplicate studies yielded 162 articles. After excluding all articles that did not meet the inclusion criteria, 56 studies were gathered. Among the 56 studies, 36 analyzed serum biomarkers; 11, neuroimaging biomarkers; and 9, cerebrospinal fuid (CSF) biomarkers. Most studies assessed biomarkers in the serum, refecting the feasibility of obtaining blood samples compared to obtaining CSF or performing neuroimaging. S100B was the most studied serum biomarker in TBI, followed by SNE and UCH-L1, whereas in CSF analysis, there was no unanimity. Among the diferent neuroimaging techniques employed, difusion tensor imag ing (DTI) was the most common, seemingly holding diagnostic power in the pediatric TBI clinical setting. The number of cross-sectional studies was similar to the number of longitudinal studies. Our data suggest that S100B measurement has high sensitivity and great promise in diagnosing pediatric TBI, ideally when associated with head CT examination and clinical decision protocols. Further large-scale longitudinal studies addressing TBI biomarkers in children are required to establish more accurate diagnostic protocols and prognostic tools. |
| Subject: | Lesões Encefálicas Traumáticas Pediatria Biomarcadores Farmacológicos Subunidade beta da Proteína Ligante de Cálcio S100 Neuroimagem |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE MORFOLOGIA MED - DEPARTAMENTO DE PEDIATRIA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1007/s10143-021-01588-0 |
| URI: | http://hdl.handle.net/1843/57269 |
| Issue Date: | 2022 |
| metadata.dc.url.externa: | https://link.springer.com/article/10.1007/s10143-021-01588-0 |
| metadata.dc.relation.ispartof: | Neurosurgical Review |
| Appears in Collections: | Artigo de Periódico |
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