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http://hdl.handle.net/1843/57446| Type: | Artigo de Periódico |
| Title: | Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil |
| Authors: | Rosângela Maria Gomes Brian Godman Francisco de Assis Acurcio Augusto Afonso Guerra Júnior Lívia Lovato Pires de Lemos Juliana de Oliveira Costa Alessandra Almeida Maciel Juliana Alvares Charles Simão Filho Mariângela Leal Cherchiglia Eli Iola Gurgel Andrade |
| Abstract: | Background: Cyclosporine and tacrolimus are well established immunosuppressants; however little know about long term survival rates. Aim: Compare 10-year graft survival and associated factors among kidney transplant patients within the Brazilian Public Health system (SUS) prescribed either medicine. Methods: Analyze a national cohort of kidney transplant recipients within SUS. Graft loss defined by death or dialysis for more than three months. Kaplan-Meier method used to estimate cumulative probabilities of survival. Cox proportional hazards modelused to evaluate factors associated with progression to graft loss. Results: 13,811 patients were included, 5,887 used cyclosporine and 7,924 tacrolimus. A higher risk of graft loss was associated with tacrolimus, a deceased donor, additional years of age, median period of dialysis greater than 47 months, diagnosis of diabetes as the primary cause of chronic kidney disease and transplantation between 2005 and 2009. Conclusions: Among other factors, tacrolimus based regimens were associated with worse graft survival. |
| Subject: | Transplante de Rim Análise de Sobrevida Ciclosporina Estimativa de Kaplan-Meier |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE FARMÁCIA SOCIAL MED - DEPARTAMENTO DE CIRURGIA MED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIAL |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1080/17512433.2016.1190270 |
| URI: | http://hdl.handle.net/1843/57446 |
| Issue Date: | 2016 |
| metadata.dc.url.externa: | https://www.tandfonline.com/doi/abs/10.1080/17512433.2016.1190270 |
| metadata.dc.relation.ispartof: | Expert Review of Clinical Pharmacology |
| Appears in Collections: | Artigo de Periódico |
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