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http://hdl.handle.net/1843/57580| Type: | Artigo de Periódico |
| Title: | Increased N200 and P300 latencies in cognitively impaired elderly carrying ApoE ε-4 allele |
| Authors: | Marco Túlio Gualberto Cintra Nilton Alves de Rezende Maria Aparecida Camargos Bicalho Rafaela Ávila Thayana Oliveira Soares Luciana Cristina Matos Cunha Katia Daniela Silveira Edgar Nunes Moraes Kaique Roger Simas Renato Bragança Fernandes Denise Utsch Gonçalves |
| Abstract: | Objective: To compare the results of neuropsychological tests, evoked potentials N200 andP300 and polymorphisms of ApoE and BDNF rs6265 between patients with normal cognition and those with mild cognitive impairment (MCI) and Alzheimer's dementia (AD). Methods: This is a cross‐sectional study of elderly individuals with normal cognition and those with MCI and AD, who were submitted to evoked potential tests (N200 and P300) by means of hearing stimuli based on the auditory oddball paradigm. Genotyping was obtained by using the real‐time PCR technique.Results: Sixty‐five patients were evaluated as follows: 14 controls, 34 with MCI and 17 with AD. N200 latency and P300 latency and amplitude were not associated with MCI and AD diagnosis. Patients with cognitive impairment (MCI or AD) showed increase in the latencies of P300 and N200. BNDF gene was not associated with cognitive impairment.Conclusion: Latencies of N200 and P300 increased in cognitively impaired patients with the presence of ApoE ε‐4 allele. |
| Subject: | Doença de Alzheimer Apolipoproteínas E Potenciais Evocados Auditivos Fator Neurotrófico Derivado do Encéfalo Disfunção Cognitiva |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1002/gps.4773 |
| URI: | http://hdl.handle.net/1843/57580 |
| Issue Date: | 2018 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/journal/10991166 |
| metadata.dc.relation.ispartof: | International Journal of Geriatric Psychiatry |
| Appears in Collections: | Artigo de Periódico |
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