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Type:	Artigo de Periódico
Title:	Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen
Authors:	Luara Isabela dos Santos Thais Abdala Torres Suelen Queiroz Diniz Ricardo Gonçalves Gustavo Caballero-flores Gabriel Núñez Ricardo Tostes Gazzinelli Kevin Joseph Maloy Lis Ribeiro do v. Antonelli
Abstract:	Individuals with malaria exhibit increased morbidity and mortality when infected with Gram-negative (Gr−) bacteria. To explore this experimentally, we performed co-infection of mice with Plasmodium chabaudi and Citrobacter rodentium, an extracellular Gr− bacterial pathogen that infects the large intestine. While single infections are controlled effectively, co-infection results in enhanced virulence that is characterized by prolonged systemic bacterial persistence and high mortality. Mortality in co-infected mice is associated with disrupted iron metabolism, elevated levels of plasma heme, and increased mitochondrial reactive oxygen species (ROS) production by phagocytes. In addition, iron acquisition by the bacterium plays a key role in pathogenesis because co-infection with a mutant C. rodentium strain lacking a critical iron acquisition pathway does not cause mortality. These results indicate that disrupted iron metabolism may drive mortality during co-infection with C. rodentium and P. chabaudi by both altering host immune responses and facilitating bacterial persistence.
Subject:	Metabolismo Malária
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE PATOLOGIA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1016/j.celrep.2020.108613
URI:	http://hdl.handle.net/1843/58678
Issue Date:	2021
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/pii/S2211124720316028?via%3Dihub
metadata.dc.relation.ispartof:	Cell Reports
Appears in Collections:	Artigo de Periódico

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