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http://hdl.handle.net/1843/59341| Type: | Artigo de Periódico |
| Title: | Maytenus distichophylla and Salacia crassifolia: source of products with potential acetylcholinesterase inhibition |
| Authors: | Fernanda L. Ferreira Vanessa G. Rodrigues Fernando C. Silva Bibiane L. G. Matildes Jacqueline Aparecida Takahashi Gracia D. F. Silva Lucienir P. Duarte Djalma M. Oliveira Sidney A. V. Filho |
| Abstract: | The phytochemical study of the extract leaves from Maytenus distichophylla Mart. and Salacia crassifolia (Mart. ex Schult.) G. Don, Celastraceae, resulted in the isolation of 3-oxofriedelane, 3-hydroxyfriedelane, 3,24-dihydroxyfriedelane, 3-oxo-28,29-dihydroxyfriedelane, two mixtures of pentacyclic triterpenes (-amyrin with -amyrin and 3-stearyloxy-urs-12-ene with 3-stearyloxy-olean-12-ene), 3- palmityloxy-urs-12-ene, the steroid -sitosterol and its glycosylated derivative -glucosyl--sitosterol, tritriacontanoic acid and the natural polymer gutta percha. The chemical structures of these constituents were established by IR, 1H and 13C NMR spectral data. Crude extracts, the mixtures of triterpenes and the isolated constituents were subjected to in vitro acetylcholinesterase inhibitory evaluation. Acetylcholinesterase inhibitory effect was observed for crude chloroform extract leaves from M. distichophylla (100%) and S. crassifolia (97.93 ± 5.63%) and for the triterpenes 3,24-dihydroxyfriedelane (99.05 ± 1.12%), 3-oxo-28,29-dihydroxyfriedelane (90.59 ± 3.76%) and 3-palmityloxy-urs-12-ene (97.93 ± 1.47%). The percent inhibitions induced by these natural products were very similar to those produced by physostigmine (93.94 ± 2.10%) a standard acetylcholinesterase inhibitor. Therefore, these results open perspectives for the use of these species as source of compounds with similar physostigmine pharmacological effect. |
| Subject: | Produtos naturais Fitoquímicos |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAE - DEPARTAMENTO DE MÉTODOS E TÉCNICAS DE ENSINO FAE - FACULDADE DE EDUCAÇÃO ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.bjp.2016.12.006 |
| URI: | http://hdl.handle.net/1843/59341 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0102695X1630206X?via%3Dihub |
| metadata.dc.relation.ispartof: | Revista Brasileira de Farmacognosia |
| Appears in Collections: | Artigo de Periódico |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Maytenus distichophylla and Salacia crassifolia_ source of products with potential acetylcholinesterase inhibition.pdf | 242.55 kB | Adobe PDF | View/Open |
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