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http://hdl.handle.net/1843/59346| Tipo: | Artigo de Periódico |
| Título: | Psychotria viridis: chemical constituents from leaves and biological properties |
| Autor(es): | Débora B. S. Soares Lucienir P. Duarte André D. Cavalcanti Fernando C. Silva Ariadne D. Braga Miriam T. P. Lopes Jacqueline Aparecida Takahashi Sidney A. Vieira-filho |
| Resumo: | The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1. |
| Assunto: | Tumores Fitoquímicos |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | FAE - DEPARTAMENTO DE MÉTODOS E TÉCNICAS DE ENSINO FAE - FACULDADE DE EDUCAÇÃO ICB - DEPARTAMENTO DE FARMACOLOGIA ICX - DEPARTAMENTO DE QUÍMICA |
| Tipo de Acesso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.1590/0001-3765201720160411 |
| URI: | http://hdl.handle.net/1843/59346 |
| Data do documento: | 2017 |
| metadata.dc.url.externa: | https://www.scielo.br/j/aabc/a/yj9LRqGsz4RZRTh9rVNpy9j/?lang=en |
| metadata.dc.relation.ispartof: | Academia Brasileira de Ciências |
| Aparece nas coleções: | Artigo de Periódico |
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| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Psychotria viridis_ Chemical constituents from leaves and biological properties.pdf | 438.98 kB | Adobe PDF | Visualizar/Abrir |
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