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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59346
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dc.creatorDébora B. S. Soarespt_BR
dc.creatorLucienir P. Duartept_BR
dc.creatorAndré D. Cavalcantipt_BR
dc.creatorFernando C. Silvapt_BR
dc.creatorAriadne D. Bragapt_BR
dc.creatorMiriam T. P. Lopespt_BR
dc.creatorJacqueline Aparecida Takahashipt_BR
dc.creatorSidney A. Vieira-filhopt_BR
dc.date.accessioned2023-10-09T23:21:04Z-
dc.date.available2023-10-09T23:21:04Z-
dc.date.issued2017-
dc.citation.volume89pt_BR
dc.citation.issue2pt_BR
dc.citation.spage927pt_BR
dc.citation.epage938pt_BR
dc.identifier.doihttps://doi.org/10.1590/0001-3765201720160411pt_BR
dc.identifier.issn0001-3765pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59346-
dc.description.resumoThe phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAE - DEPARTAMENTO DE MÉTODOS E TÉCNICAS DE ENSINOpt_BR
dc.publisher.departmentFAE - FACULDADE DE EDUCAÇÃOpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAcademia Brasileira de Ciênciaspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPsychotria viridispt_BR
dc.subjectRubiaceaept_BR
dc.subjectN,N-dimethyltryptaminept_BR
dc.subjectB16F10pt_BR
dc.subject4T1 tumor cellspt_BR
dc.subject.otherTumorespt_BR
dc.subject.otherFitoquímicospt_BR
dc.titlePsychotria viridis: chemical constituents from leaves and biological propertiespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/aabc/a/yj9LRqGsz4RZRTh9rVNpy9j/?lang=enpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8831-1609pt_BR
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