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http://hdl.handle.net/1843/59347| Tipo: | Artigo de Periódico |
| Título: | A New Acetylcholinesterase Inhibitor from Green Glycosylation of Trachyloban-19-oic Acid by Mucor plumbeus |
| Autor(es): | Gabriel F. Dossantos Jacqueline Aparecida Takahashi |
| Resumo: | The in vitro metabolism of a widespread natural product, trachyloban-19-oic acid (1), by the fungal species Mucor plumbeus was studied in a sucrose-yeast liquid medium. Two products were isolated, and their structures were determined by spectroscopic means as 7β-hydroxytrachyloban-19-oic acid (5) and trachyloban-19-O-β-D-glucopyranosyl ester (6). To the best of our knowledge, compound 6 is herein reported by the first time in the literature. These compounds were assayed for acetylcholinesterase inhibition along with some related compounds. Compound 6 showed the highest acetylcholinesterase inhibitory activity at 10000 µg/mL among the tested compounds, a result (92.89%) comparable to the activity of the positive control, galanthamine (94.21%). Therefore, biotransformation of the natural product 1 by M. plumbeus produced a novel compound with potential as a new lead to develop anti-Alzheimer medicines. |
| Assunto: | Biotransformação (Metabolismo) Inibidores Química |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | ICX - DEPARTAMENTO DE QUÍMICA |
| Tipo de Acesso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.1590/0001-3765201720170240 |
| URI: | http://hdl.handle.net/1843/59347 |
| Data do documento: | 2017 |
| metadata.dc.url.externa: | https://www.scielo.br/j/aabc/a/sWrhpW3MQ8pYtkPDHpq58sK/?lang=en |
| metadata.dc.relation.ispartof: | Academia Brasileira de Ciências |
| Aparece nas coleções: | Artigo de Periódico |
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| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| A New Acetylcholinesterase Inhibitor from Green Glycosylation of Trachyloban-19-oic Acid by Mucor plumbeus.pdf | 474.08 kB | Adobe PDF | Visualizar/Abrir |
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