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http://hdl.handle.net/1843/59347
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DC Field | Value | Language |
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dc.creator | Gabriel F. Dossantos | pt_BR |
dc.creator | Jacqueline Aparecida Takahashi | pt_BR |
dc.date.accessioned | 2023-10-09T23:21:32Z | - |
dc.date.available | 2023-10-09T23:21:32Z | - |
dc.date.issued | 2017 | - |
dc.citation.volume | 86 | pt_BR |
dc.citation.issue | 3 | pt_BR |
dc.citation.spage | 1961 | pt_BR |
dc.citation.epage | 1969 | pt_BR |
dc.identifier.doi | https://doi.org/10.1590/0001-3765201720170240 | pt_BR |
dc.identifier.issn | 0001-3765 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/1843/59347 | - |
dc.description.resumo | The in vitro metabolism of a widespread natural product, trachyloban-19-oic acid (1), by the fungal species Mucor plumbeus was studied in a sucrose-yeast liquid medium. Two products were isolated, and their structures were determined by spectroscopic means as 7β-hydroxytrachyloban-19-oic acid (5) and trachyloban-19-O-β-D-glucopyranosyl ester (6). To the best of our knowledge, compound 6 is herein reported by the first time in the literature. These compounds were assayed for acetylcholinesterase inhibition along with some related compounds. Compound 6 showed the highest acetylcholinesterase inhibitory activity at 10000 µg/mL among the tested compounds, a result (92.89%) comparable to the activity of the positive control, galanthamine (94.21%). Therefore, biotransformation of the natural product 1 by M. plumbeus produced a novel compound with potential as a new lead to develop anti-Alzheimer medicines. | pt_BR |
dc.description.sponsorship | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico | pt_BR |
dc.description.sponsorship | FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais | pt_BR |
dc.format.mimetype | pt_BR | |
dc.language | eng | pt_BR |
dc.publisher | Universidade Federal de Minas Gerais | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.department | ICX - DEPARTAMENTO DE QUÍMICA | pt_BR |
dc.publisher.initials | UFMG | pt_BR |
dc.relation.ispartof | Academia Brasileira de Ciências | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.subject | Acetylcholinesterase inhibitors | pt_BR |
dc.subject | Biotransformation | pt_BR |
dc.subject | Green glycosylation | pt_BR |
dc.subject | Mucor plumbeus | pt_BR |
dc.subject | Trachyloban-19-oic acid | pt_BR |
dc.subject.other | Biotransformação (Metabolismo) | pt_BR |
dc.subject.other | Inibidores | pt_BR |
dc.subject.other | Química | pt_BR |
dc.title | A New Acetylcholinesterase Inhibitor from Green Glycosylation of Trachyloban-19-oic Acid by Mucor plumbeus | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.url.externa | https://www.scielo.br/j/aabc/a/sWrhpW3MQ8pYtkPDHpq58sK/?lang=en | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0002-8831-1609 | pt_BR |
Appears in Collections: | Artigo de Periódico |
Files in This Item:
File | Description | Size | Format | |
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A New Acetylcholinesterase Inhibitor from Green Glycosylation of Trachyloban-19-oic Acid by Mucor plumbeus.pdf | 474.08 kB | Adobe PDF | View/Open |
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