1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59347
Full metadata record
DC FieldValueLanguage
dc.creatorGabriel F. Dossantospt_BR
dc.creatorJacqueline Aparecida Takahashipt_BR
dc.date.accessioned2023-10-09T23:21:32Z-
dc.date.available2023-10-09T23:21:32Z-
dc.date.issued2017-
dc.citation.volume86pt_BR
dc.citation.issue3pt_BR
dc.citation.spage1961pt_BR
dc.citation.epage1969pt_BR
dc.identifier.doihttps://doi.org/10.1590/0001-3765201720170240pt_BR
dc.identifier.issn0001-3765pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59347-
dc.description.resumoThe in vitro metabolism of a widespread natural product, trachyloban-19-oic acid (1), by the fungal species Mucor plumbeus was studied in a sucrose-yeast liquid medium. Two products were isolated, and their structures were determined by spectroscopic means as 7β-hydroxytrachyloban-19-oic acid (5) and trachyloban-19-O-β-D-glucopyranosyl ester (6). To the best of our knowledge, compound 6 is herein reported by the first time in the literature. These compounds were assayed for acetylcholinesterase inhibition along with some related compounds. Compound 6 showed the highest acetylcholinesterase inhibitory activity at 10000 µg/mL among the tested compounds, a result (92.89%) comparable to the activity of the positive control, galanthamine (94.21%). Therefore, biotransformation of the natural product 1 by M. plumbeus produced a novel compound with potential as a new lead to develop anti-Alzheimer medicines.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAcademia Brasileira de Ciênciaspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAcetylcholinesterase inhibitorspt_BR
dc.subjectBiotransformationpt_BR
dc.subjectGreen glycosylationpt_BR
dc.subjectMucor plumbeuspt_BR
dc.subjectTrachyloban-19-oic acidpt_BR
dc.subject.otherBiotransformação (Metabolismo)pt_BR
dc.subject.otherInibidorespt_BR
dc.subject.otherQuímicapt_BR
dc.titleA New Acetylcholinesterase Inhibitor from Green Glycosylation of Trachyloban-19-oic Acid by Mucor plumbeuspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/aabc/a/sWrhpW3MQ8pYtkPDHpq58sK/?lang=enpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8831-1609pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
A New Acetylcholinesterase Inhibitor from Green Glycosylation of Trachyloban-19-oic Acid by Mucor plumbeus.pdf474.08 kBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.