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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59489
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dc.creatorPereira Almeida Sirleypt_BR
dc.creatorAntonio a de Melo Filhopt_BR
dc.creatorFernanda Guilhom Simpliciopt_BR
dc.creatorM. G. Martins Regildopt_BR
dc.creatorJacqueline Aparecida Takahashipt_BR
dc.creatorVany P. Ferrazpt_BR
dc.creatorAna Cristina G. Reis de Melopt_BR
dc.creatorPedro Tadei Wanderlipt_BR
dc.date.accessioned2023-10-16T21:44:05Z-
dc.date.available2023-10-16T21:44:05Z-
dc.date.issued2018-
dc.citation.volume64pt_BR
dc.citation.spage271pt_BR
dc.citation.epage276pt_BR
dc.identifier.doihttps://doi.org/10.3303/CET1864046pt_BR
dc.identifier.issn2283-9216pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59489-
dc.description.resumoThe aim of this study was to evaluate the influence of seasonality on the chemical composition of the essential oil from Hyptis dilatata leaves, to perform biological activity assays such as antimicrobial, inhibition of acetylcholinesterase enzyme and to evaluate the toxicity of the essential oil using Artemia salina as indicator on the test. Hyptis dilatata leaves were collected in rainy and dry seasons, in the morning, in the afternoon and in the evening. It was extracted by hydrodistillation using the extractor of Clevenger condenser double Spell model. The essential oil analysis resulted in 22 chemical components. The major constituents of the dry and rainy periods were α-pinene (18.7% in the night and 12.9% in the afternoon), 3-carene (26.5% and 19.9% in the night), fenchone (43% and 33.7% in the morning) and β-caryophyllene 9.1% in the afternoon and 6.1% in the morning. The essential oil in vitro inhibited the acetylcholinesterase enzyme in 99.9% in the afternoon (rainy period) and 96.4% in the morning (dry period). Between the dry and rainy seasons, the lowest LC50 microbial activity in vitro was obtained for leaves collected during rainy season, in the morning period tested against the bacterium Staphylococcus aureus (LC50 78.1 mg mL-1). The cytotoxic activity of the essential oil of H. dilatata on Artemia salina showed LC50 results below 100 μg mL-1 and in the afternoon during the rainy period and at night in the dry period the results are above this value. Therefore, the chemical characterization and biological activities tests of essential oils showed promising results in the search for new active substances and the development of bioproducts of vegetable origin.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofChemical Engineering Transactionspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectQuímicapt_BR
dc.subjectProdutos de ação antimicrobianapt_BR
dc.subjectEssências e Óleos Essenciaispt_BR
dc.subject.otherQuímicapt_BR
dc.subject.otherProdutos de ação antimicrobianapt_BR
dc.subject.otherEssências e Óleos Essenciaispt_BR
dc.titleChemical Profile, Toxicity, Anti-Acetylcholinesterase and Anti-microbial Activity of Essential Oil from Hyptis dilatata Leavept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.aidic.it/cet/18/64/046.pdfpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8831-1609pt_BR
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