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Type:	Artigo de Periódico
Title:	Chemical Profile, Toxicity, Anti-Acetylcholinesterase and Anti-microbial Activity of Essential Oil from Hyptis dilatata Leave
Authors:	Pereira Almeida Sirley Antonio a de Melo Filho Fernanda Guilhom Simplicio M. G. Martins Regildo Jacqueline Aparecida Takahashi Vany P. Ferraz Ana Cristina G. Reis de Melo Pedro Tadei Wanderli
Abstract:	The aim of this study was to evaluate the influence of seasonality on the chemical composition of the essential oil from Hyptis dilatata leaves, to perform biological activity assays such as antimicrobial, inhibition of acetylcholinesterase enzyme and to evaluate the toxicity of the essential oil using Artemia salina as indicator on the test. Hyptis dilatata leaves were collected in rainy and dry seasons, in the morning, in the afternoon and in the evening. It was extracted by hydrodistillation using the extractor of Clevenger condenser double Spell model. The essential oil analysis resulted in 22 chemical components. The major constituents of the dry and rainy periods were α-pinene (18.7% in the night and 12.9% in the afternoon), 3-carene (26.5% and 19.9% in the night), fenchone (43% and 33.7% in the morning) and β-caryophyllene 9.1% in the afternoon and 6.1% in the morning. The essential oil in vitro inhibited the acetylcholinesterase enzyme in 99.9% in the afternoon (rainy period) and 96.4% in the morning (dry period). Between the dry and rainy seasons, the lowest LC50 microbial activity in vitro was obtained for leaves collected during rainy season, in the morning period tested against the bacterium Staphylococcus aureus (LC50 78.1 mg mL-1). The cytotoxic activity of the essential oil of H. dilatata on Artemia salina showed LC50 results below 100 μg mL-1 and in the afternoon during the rainy period and at night in the dry period the results are above this value. Therefore, the chemical characterization and biological activities tests of essential oils showed promising results in the search for new active substances and the development of bioproducts of vegetable origin.
Subject:	Química Produtos de ação antimicrobiana Essências e Óleos Essenciais
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICX - DEPARTAMENTO DE QUÍMICA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.3303/CET1864046
URI:	http://hdl.handle.net/1843/59489
Issue Date:	2018
metadata.dc.url.externa:	https://www.aidic.it/cet/18/64/046.pdf
metadata.dc.relation.ispartof:	Chemical Engineering Transactions
Appears in Collections:	Artigo de Periódico

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