Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/59559| Type: | Artigo de Periódico |
| Title: | Expression of cell cycle proteins according to HPV status in oral squamous cell carcinoma affecting young patients: a pilot study |
| Authors: | Marisol Miranda-Galvis Jucelino Freitas Jardim Estela Kaminagakura Tango Alan Roger dos Santos-Silva Felipe Paiva Fonseca Oslei Paes de Almeida Márcio Ajudarte Lopes Clóvis Antonio Lopes Pinto Luiz Paulo Kowalski |
| Abstract: | Objective: Tobacco and alcohol consumption are considered the main risk factors for oral squamous cell carcinoma (OSCC); however, the role of these factors in patients younger than 40 years is controversial, so it has been suggested that genomic instability and high-risk human papillomavirus (HR-HPV) infection may be contributing factors to oral carcinogenesis at a young age. Therefore, the aim of this study was to evaluate the immunoexpression of cell cycle proteins according HPV status in OSCC affecting young patients. Methods: A tissue microarray construction based on 34 OSCC samples from young patients (<40 years old) was subjected to immunohistochemical reactions for Ki67, cyclin D1, C-ErbB2, p21, Myc, epidermal growth factor receptor, p53, and p16 antibodies. Results: The clinicopathologic features and the immunoexpression of all tested proteins were similar in both groups. Patients with HPV-related OSSC tended to have better cancer-specific survival (CSS; 39% vs 60% 5-y CSS), and overall survival (OS; 29.2% vs 60% 5-year OS). However, this difference was not statistically significant. Conclusion: No significant difference exists in the expression of cell cycle proteins studied between HR-HPV DNA-positive and HR-HPV DNA-negative OSCC affecting young patients. |
| Subject: | Proteins Carcinoma Human papillomavirus viruses Immunohistochemistry Survival DNA |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.oooo.2018.01.003 |
| URI: | http://hdl.handle.net/1843/59559 |
| Issue Date: | Apr-2018 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S2212440318300397?via%3Dihub |
| metadata.dc.relation.ispartof: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Expression of cell cycle proteins according to HPV status in oral squamous cell carcinoma affecting young patients a pilot study.pdf | 3.29 MB | Adobe PDF | View/Open |
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