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http://hdl.handle.net/1843/59785| Type: | Artigo de Periódico |
| Title: | Activation of BDNF/trkB/Akt pathway is associated with aggressiveness and unfavorable survival in oral squamous cell carcinoma |
| Authors: | Juliana Kern de Moraes Vivian Petersen Wagner Felipe Paiva Fonseca Gleyson Kleber do Amaral Silva Pablo Agustin Vargas Manoela Domingues Martins Caroline Brunetto de Farias Emily Ferreira Salles Pilar Lauro Gregianin Rafael Roesler |
| Abstract: | Objectives: To evaluate the expression of brain-derived neurotrophic factor (BDNF), its tyrosine kinase receptor B (TrkB), and two downstream targets of this pathway, Akt and ribosomal protein S6 (RPS6), in normal oral mucosa (NOM), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC) and correlate this expression with OSCC patients' outcomes, cell senescence, and "stemness" profile. Materials and methods: Ten cases of NOM, 32 OL, and 72 primary OSCC were included. Immunohistochemical analysis for BDNF, TrkB, p-TrkB, p-Akt, and p-RPS6 was performed. Cell senescence and stemness profile of OSCC were evaluated through p16 and BMI-1 immunohistochemical expression, respectively. The slides were scanned into high-resolution images and quantified through digital analysis. Results: Oral squamous cell carcinoma presented increased expression of BDNF/TrkB/Akt pathway compared to NOM and OL. OSCC diagnosed in advanced clinical stages presented an upregulation of BDNF and p-TrkB. BDNF and p-Akt were identified as predictors of poor disease-specific survival. The increase in stemness profile was correlated with a decrease in p-TrkB and p-Akt expression. Conclusions: BDNF/TrkB/Akt pathway is significantly increased in malignant cells from OSCC. Moreover, BDNF and Akt represent biomarkers capable to predict a poor prognosis of OSCC patients. |
| Subject: | Biomarkers Head and neck neoplasms Immunohistochemistry Predictive value of tests Prognosis Brain-derived neurotrophic factor Receptor, trkB Squamous cell carcinoma of head and neck Proteins Mouth mucosa Leukoplakia, oral Survival Aging |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1111/odi.13190 |
| URI: | http://hdl.handle.net/1843/59785 |
| Issue Date: | 2019 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/10.1111/odi.13190 |
| metadata.dc.relation.ispartof: | Oral Diseases |
| Appears in Collections: | Artigo de Periódico |
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