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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59824
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dc.creatorBárbara Martins de Andradept_BR
dc.creatorSara Ferreira dos Santos Costapt_BR
dc.creatorMaria Sissa Pereira Sant'anapt_BR
dc.creatorAlbina Altemanipt_BR
dc.creatorPablo Agustin Vargaspt_BR
dc.creatorEduardo Rodrigues Fregnanipt_BR
dc.creatorLucas Guimarães Abreupt_BR
dc.creatorAline Carvalho Batistapt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.date.accessioned2023-10-20T20:20:29Z-
dc.date.available2023-10-20T20:20:29Z-
dc.date.issued2019-06-
dc.citation.volume93pt_BR
dc.citation.spage52pt_BR
dc.citation.epage58pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.oraloncology.2019.04.014pt_BR
dc.identifier.issn13688375pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59824-
dc.description.resumoThe presence of lymphovascular invasion is considered a prognostic determinant for different human neoplasms and is frequently taken into account by surgeons and oncologists to determine patients' treatment. However, the exact frequency of this microscopic event and its prognostic impact for patients affected by adenoid cystic carcinoma (AdCC) remains unclear. Therefore, the aim of this study was to carry out a systematic review and meta-analysis to address the prevalence and the prognostic potential of lymphovascular invasion in head and neck AdCC. A literature search on PubMed, Scopus, ClinicalTrials.gov, Web of Science and ProQuest databases was undertaken in January 2019. The primary outcomes of interest were overall survival (OS) and disease-free survival (DFS). The relative frequency of lymphovascular invasion and its possible association with other clinicopathological parameters were addressed. A total of 22 studies and 2117 patients were included in this study. The frequency of lymphovascular invasion ranged from 5.2% to 72.5%. Lymphovascular invasion was associated with an increased likelihood of lymph node metastasis (OR = 2.58; 95% CI 1.61-4.12; p = 0.0001) and death (OR = 3.09; 95% CI 1.82-5.26; p = 0.0001), solid/higher-grade AdCC were more likely to present lymphovascular invasion (OR = 5.51; 95% CI 1.87-16-21; p = 0.002) and patients with this microscopic finding had a significantly lower OS (HR = 8.30; 95% CI 1.68-40.91; p = 0.009) and DFS (HR = 3.76; 95% CI 1.13-12.53; p = 0.03). In conclusion, lymphovascular invasion seems to be a significant predictor of poor prognosis for head and neck AdCC patients.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofOral Oncologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherCarcinoma, adenoid cysticpt_BR
dc.subject.otherHead and neck neoplasmspt_BR
dc.subject.otherPrognosispt_BR
dc.subject.otherAdenoma, pleomorphicpt_BR
dc.subject.otherPrevalencept_BR
dc.subject.otherCross-sectional studiespt_BR
dc.subject.otherDeathpt_BR
dc.subject.otherSurvivalpt_BR
dc.subject.otherLymphatic metastasispt_BR
dc.titlePrognostic importance of the lymphovascular invasion in head and neck adenoid cystic carcinoma: a systematic review and meta-analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1368837519301253?via%3Dihubpt_BR
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