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Type:	Artigo de Periódico
Title:	Prognostic importance of the lymphovascular invasion in head and neck adenoid cystic carcinoma: a systematic review and meta-analysis
Authors:	Bárbara Martins de Andrade Sara Ferreira dos Santos Costa Maria Sissa Pereira Sant'ana Albina Altemani Pablo Agustin Vargas Eduardo Rodrigues Fregnani Lucas Guimarães Abreu Aline Carvalho Batista Felipe Paiva Fonseca
Abstract:	The presence of lymphovascular invasion is considered a prognostic determinant for different human neoplasms and is frequently taken into account by surgeons and oncologists to determine patients' treatment. However, the exact frequency of this microscopic event and its prognostic impact for patients affected by adenoid cystic carcinoma (AdCC) remains unclear. Therefore, the aim of this study was to carry out a systematic review and meta-analysis to address the prevalence and the prognostic potential of lymphovascular invasion in head and neck AdCC. A literature search on PubMed, Scopus, ClinicalTrials.gov, Web of Science and ProQuest databases was undertaken in January 2019. The primary outcomes of interest were overall survival (OS) and disease-free survival (DFS). The relative frequency of lymphovascular invasion and its possible association with other clinicopathological parameters were addressed. A total of 22 studies and 2117 patients were included in this study. The frequency of lymphovascular invasion ranged from 5.2% to 72.5%. Lymphovascular invasion was associated with an increased likelihood of lymph node metastasis (OR = 2.58; 95% CI 1.61-4.12; p = 0.0001) and death (OR = 3.09; 95% CI 1.82-5.26; p = 0.0001), solid/higher-grade AdCC were more likely to present lymphovascular invasion (OR = 5.51; 95% CI 1.87-16-21; p = 0.002) and patients with this microscopic finding had a significantly lower OS (HR = 8.30; 95% CI 1.68-40.91; p = 0.009) and DFS (HR = 3.76; 95% CI 1.13-12.53; p = 0.03). In conclusion, lymphovascular invasion seems to be a significant predictor of poor prognosis for head and neck AdCC patients.
Subject:	Carcinoma, adenoid cystic Head and neck neoplasms Prognosis Adenoma, pleomorphic Prevalence Cross-sectional studies Death Survival Lymphatic metastasis
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	FAO - DEPARTAMENTO DE CLÍNICA FAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1016/j.oraloncology.2019.04.014
URI:	http://hdl.handle.net/1843/59824
Issue Date:	Jun-2019
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/pii/S1368837519301253?via%3Dihub
metadata.dc.relation.ispartof:	Oral Oncology
Appears in Collections:	Artigo de Periódico

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