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http://hdl.handle.net/1843/59950| Type: | Artigo de Periódico |
| Title: | Acute lymphoblastic leukemia/lymphoma of the oral and maxillofacial region |
| Authors: | Celeste Sánchez-Romero Hélder Antônio Rebelo Pontes Flávia Sirotheau Corrêa Pontes André Caroli Rocha Román Carlos Javier Rendon Oslei Paes de Almeida Felipe Paiva Fonseca |
| Abstract: | Objective: Our objective was to describe the clinicopathologic and immunohistochemical features of acute lymphoblastic leukemia/lymphoma (ALL/LBL) of the oral and maxillofacial region (OMF). Study design: Cases diagnosed as ALL/LBL of the OMF region were retrieved from the files of 2 Brazilian and 1 Guatemalan oral pathology services from 2005 to 2017. Microscopic and immunohistochemical features of each case were reviewed and fully described, and clinical data were retrieved from the pathology reports. Results: During the period considered, 6 cases were identified. Male patients were the most affected (4:2), with a mean age of 19 years old. The mandible was involved in 2 cases, the maxilla in 2, the cheek mucosa in 1, and the parotid gland in 1. Painful swelling was the most common presentation, and 3 patients also had systemic complaints. Microscopically, tumors revealed solid infiltrations of small to medium-sized immature cells. "Puzzle-like" and "starry-sky" patterns were observed, and "single lane" growth was also identified. Immunohistochemically, 2 cases were diagnosed as T-cell ALL/LBL with the leukocyte common antigen (LCA)+/cCD3+/CD79 a+focal/CD20-/PAX5-/CD99+/CD34-/CD10+/terminal deoxynucleotidyl transferase (TdT)+ phenotype and 4 as B-cell ALL/LBL with the LCA+/CD3-/CD20-/CD79 a+/CD10+/CD34 variable/TdT+ predominant phenotype. The Ki67 index ranged from 80% to 99%. Conclusion: OMF ALL/LBL is rare, but its microscopic features and immunohistochemical profiles CD3+or CD79 a+/CD10+/CD34+variable/CD99+/TdT+ contribute to the correct diagnosis. |
| Subject: | Leukemia Lymphoma Immunohistochemistry Pathology, oral |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://www.sciencedirect.com/science/article/pii/S2212440318300464?via%3Dihub |
| URI: | http://hdl.handle.net/1843/59950 |
| Issue Date: | Aug-2018 |
| metadata.dc.url.externa: | https://doi.org/10.1016/j.oooo.2018.01.010 |
| metadata.dc.relation.ispartof: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology |
| Appears in Collections: | Artigo de Periódico |
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