Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59998
Type: Artigo de Periódico
Title: Protein-coding gene interaction network prediction of bioactive plant compound action against SARS-CoV-2: a novel hypothesis using bioinformatics analysis
Authors: Eliane Macedo Sobrinho Santos
Anna Christina de Almeida
Hércules Otacilio Santos
Ernane Ronie Martins
Francine Souza Alves da Fonseca
Lucyana Conceição Farias
Charles Martins Aguilar
Ulisses Alves Pereira
Nilson Nicolau Junior
Matheus de Souza Gomes
Cintya Neves de Souza
João Matheus de Almeida Ravnjak
Raphael Rodrigues Porto
Abstract: This study aimed to verify the action of bioactive compounds from Brazilian plants on the leader genes involved in the SARS-CoV-2 pathway. The main human genes involved were identified in GeneCards and UNIPROT platforms, and an interaction network between leader genes was established in the STRING database. To design chemo-biology interactome networks and elucidate the interplay between genes related to the disease and bioactive plant compounds, the metasearch engine STITCH 3.1 was used. The analysis revealed that SMAD3 and CASP3 genes are leader genes, suggesting that the mechanism of action of the virus on host cells is associated with the molecular effects of these genes. Furthermore, the bioactive plant compounds, such as ascorbate, benzoquinone, ellagic acid, and resveratrol was identified as a promising adjuvant for the treatment inhibiting CASP3-mediated apoptosis. Bioactive plant compounds were verified as the main pathways enriched with KEGG and related to viral infection, assessments/immune/infections, and cell proliferation, which are potentially used for respiratory viral infections. The best-ranked molecule docked in the CASP3 binding site was rutin, while the SMAD3 binding site was resveratrol. In conclusion, this work identified several bioactive compounds from Brazilian plants showing potential antiviral functions that can directly or indirectly inhibit the new coronavirus.
Subject: Genética
Plantas dos cerrados
Coronavirus
COVID-19 (Doença)
Plantas medicinais
language: eng
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights: Acesso Aberto
metadata.dc.identifier.doi: https://doi.org/10.1590/0001-3765202220201380
URI: http://hdl.handle.net/1843/59998
Issue Date: 2022
metadata.dc.relation.ispartof: Anais da Academia Brasileira de Ciências
Appears in Collections:Artigo de Periódico



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