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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60102
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dc.creatorDaniel Cruz Bretaspt_BR
dc.creatorCarolina Coimbra Marinhopt_BR
dc.creatorArnaldo Santos Leitept_BR
dc.creatorEliane Viana Mancuzopt_BR
dc.creatorTarciane Aline Pratapt_BR
dc.creatorBruno Horta Andradept_BR
dc.creatorJacqueline Das Graças Ferreira Oliveirapt_BR
dc.creatorAline Priscila Batistapt_BR
dc.creatorGeorge Luiz Lins Machado Coelhopt_BR
dc.creatorValéria Maria Augustopt_BR
dc.date.accessioned2023-10-26T19:39:58Z-
dc.date.available2023-10-26T19:39:58Z-
dc.date.issued2022-
dc.citation.volume26pt_BR
dc.citation.spage1pt_BR
dc.citation.epage7pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.bjid.2022.102352pt_BR
dc.identifier.issn14138670pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60102-
dc.description.resumoBackground: COVID-19 has been associated with persistent symptoms and functional changes, especially in those surviving severe disease.Methods: We conducted a prospective multicenter study in patients with severe COVID-19 to determine respiratory sequelae. Patients were stratified into two groups: ward admission (WA) and intensive care unit (ICU) admission. In each follow-up visit, the patients where inquired about cough and dyspnea, and performed spirometry, lung volumes, carbon mon oxide diffusion capacity (DLCO), 6-minute walk test (6MWT), and respiratory muscle strength (MIP and MEP). Results of pulmonary function tests at 45 days and 6 months after hospital admission were compared using paired analysis.Results: 211 patients were included, 112 in WA and 99 in ICU. Dyspnea persisted in 64.7% in the WA and 66.7% in the ICU group after 6 months. Lung function measures showed signifi cant improvement between 45 days and 6 months, both in WA and ICU groups in VC, FVC,FEV1, total lung capacity, and 6MW distance measures. The improvement in the propor tions of the altered functional parameters was significant in the ICU group for VC (44.2% 45 d; 20.8% 6 m; p = 0,014), FVC (47.6% 45 d; 28% 6 m; p = 0,003), FEV1 (45.1% 45 d; 28% 6 m;p = 0,044), DLCO (33.8% 45 d; 7.7% 6 m; p < 0,0001).Conclusion: Six months follow-up of patients with the severe forms of COVID-19 showed significant improvement in the lung function measures compared to 45 days post hospital dis charge. The difference was more evident in those requiring ICU admission.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofThe Brazilian Journal of Infectious Diseases-
dc.rightsAcesso Abertopt_BR
dc.subjectCOVID-19pt_BR
dc.subjectLung Functionpt_BR
dc.subjectFollow-Uppt_BR
dc.subjectPost-COVID conditionpt_BR
dc.subject.otherCOVID-19pt_BR
dc.subject.otherRespiratory Function Testspt_BR
dc.subject.otherFollow-Up Studiespt_BR
dc.subject.otherPost-Acute COVID-19 Syndromept_BR
dc.titleLung function six months after severe covid-19: does time, in fact, heal all wounds?pt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externadoi:10.1016/j.bjid.2022.102352pt_BR
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