Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60254
Type: Artigo de Periódico
Title: Expression of FGF-2/FGFR-1 in normal mucosa, salivary gland, preneoplastic, and neoplastic lesions of the oral cavity
Authors: Bruno Mariz
Ciro Dantas Soares
Thayna Melo de Lima Morais
Felipe Paiva Fonseca
Maria Goreti Carvalho
Jacks Jorge Junior
Abstract: Fibroblast growth factor 2 (FGF-2) is a multifunctional cytokine expressed in several tissues and involved in a wide variety of biologic activities, with one low molecular weight (LMW) protein present in the cytosol, which is secreted, acting via its receptors (FGFRs), and four high molecular weight (HMW) proteins located in the nucleus. Fibroblast growth factor receptor (FGFR) family has four (FGFR1-4) transmembrane tyrosine kinase receptors expressed on several cell types, and FGFR-1 has been indicated as a potential molecular target in several types of cancer, including oral squamous cell carcinoma (OSCC). The FGF-2/FGFR-1 expression has been studied in the oral cavity, and it was associated with the wound repair process, the development of benign and malignant salivary gland tumors, besides being related to oral potentially malignant disorders (OPMDs) and OSCC. Hence, we critically review the currently available data on FGF-2/FGFR-1 expression in the normal mucosa and lesions of the oral cavity
Subject: Fibroblast growth factors
Protein-Tyrosine Kinases
Fibroblast growth factor 2
Fibroblast growth factor 1
Proteins
Carcinoma
Mouth neoplasms
language: eng
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: FAO - DEPARTAMENTO DE CLÍNICA
Rights: Acesso Restrito
metadata.dc.identifier.doi: https://doi.org/10.1111/jop.12773
URI: http://hdl.handle.net/1843/60254
Issue Date: 2018
metadata.dc.url.externa: https://onlinelibrary.wiley.com/doi/10.1111/jop.12773
metadata.dc.relation.ispartof: Journal of Oral Pathology & Medicine
Appears in Collections:Artigo de Periódico

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