1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60398
Full metadata record
DC FieldValueLanguage
dc.creatorEmerson Soares Velosopt_BR
dc.creatorHelen Lima Del Puertopt_BR
dc.creatorEnio Ferreirapt_BR
dc.creatorBárbara Andrade de Carvalhopt_BR
dc.creatorFelipe Henrique de Souza Silvapt_BR
dc.creatorThaís Salviana Ribeiropt_BR
dc.creatorBruna Mendes Limapt_BR
dc.creatorCamila Pereira Almeidapt_BR
dc.creatorVítor Henrique Soares Romão da Silvapt_BR
dc.creatorSara Aparecida Rochapt_BR
dc.creatorMarina Rios de Araújo Campospt_BR
dc.date.accessioned2023-10-31T21:36:30Z-
dc.date.available2023-10-31T21:36:30Z-
dc.date.issued2022-10-22-
dc.citation.volume12pt_BR
dc.citation.issue1pt_BR
dc.citation.spage17776pt_BR
dc.citation.epage13pt_BR
dc.identifier.doihttps://doi.org/10.1038/s41598-022-22235-8pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60398-
dc.description.resumoMelanoma is an aggressive cancer with fast metastatic spread and reduced survival time. One common event during the neoplastic progression is the epithelial–mesenchymal transition (EMT), which enhances invasiveness, cell migration, and metastasis. In this study, we investigated the effects of metformin at EMT in melanoma cell lines B16-F10 and A-375, in vitro, and the impact of EMT downregulation on melanoma progression in vivo. The metformin cells treatment reduces the migration potential in vitro and reduced the development of pulmonary metastases and the expressions of N-cadherin, vimentin, ZEB1, and ZEB2 at the metastases site, in vivo. These results indicate that metformin can promote EMT downregulation impairing the metastatic potential of melanoma cells.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofScientific Reportspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMetástasept_BR
dc.subjectTumorespt_BR
dc.subjectMelanomapt_BR
dc.subject.otherMetástasept_BR
dc.subject.otherTumorespt_BR
dc.subject.otherMelanomapt_BR
dc.titleEpithelial–mesenchymal transition inhibition by metformin reduces melanoma lung metastasis in a murine modelpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.nature.com/articles/s41598-022-22235-8#rightslinkpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1835-0303pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
Epithelial–mesenchymal transition inhibition by metformin reduces melanoma lung metastasis in a murine model.pdf2.98 MBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.