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3. Artigo de Periódico

Type:	Artigo de Periódico
Title:	Epithelial–mesenchymal transition inhibition by metformin reduces melanoma lung metastasis in a murine model
Authors:	Emerson Soares Veloso Helen Lima Del Puerto Enio Ferreira Bárbara Andrade de Carvalho Felipe Henrique de Souza Silva Thaís Salviana Ribeiro Bruna Mendes Lima Camila Pereira Almeida Vítor Henrique Soares Romão da Silva Sara Aparecida Rocha Marina Rios de Araújo Campos
Abstract:	Melanoma is an aggressive cancer with fast metastatic spread and reduced survival time. One common event during the neoplastic progression is the epithelial–mesenchymal transition (EMT), which enhances invasiveness, cell migration, and metastasis. In this study, we investigated the effects of metformin at EMT in melanoma cell lines B16-F10 and A-375, in vitro, and the impact of EMT downregulation on melanoma progression in vivo. The metformin cells treatment reduces the migration potential in vitro and reduced the development of pulmonary metastases and the expressions of N-cadherin, vimentin, ZEB1, and ZEB2 at the metastases site, in vivo. These results indicate that metformin can promote EMT downregulation impairing the metastatic potential of melanoma cells.
Subject:	Metástase Tumores Melanoma
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICB - DEPARTAMENTO DE PATOLOGIA ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1038/s41598-022-22235-8
URI:	http://hdl.handle.net/1843/60398
Issue Date:	22-Oct-2022
metadata.dc.url.externa:	https://www.nature.com/articles/s41598-022-22235-8#rightslink
metadata.dc.relation.ispartof:	Scientific Reports
Appears in Collections:	Artigo de Periódico

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