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http://hdl.handle.net/1843/60449| Type: | Artigo de Periódico |
| Title: | EGFR is not amplified in ameloblastoma |
| Authors: | Victor Costa Eduardo Rodrigues Fregnani Felipe Paiva Fonseca Fábio Abreu Alves Clóvis Antonio Lopes Pinto Estela Kaminagakura Tango |
| Abstract: | Objective: The aim of this study was to investigate alterations in the EGFR gene and its protein expression for a better understanding of the biologic behavior of ameloblastoma. Study design: Twenty-five samples of ameloblastoma were selected, and dual-color fluorescence in situ hybridization assay was performed. The results of the assay and immunohistochemistry reaction for EGFR and Ki67 were associated with clinicopathologic features and recurrence. Results: All analyzed cases presented disomy without any gene polysomy or amplification. With regard to EGFR immunoexpression, 3 cases (12%) were considered negative, and 22 (88%) were positive, of which 13 (52%) were weak and 9 (36%) were strong. All samples presented low positivity for Ki67. There was no association between EGFR expression and clinicopathologic features or recurrence (P > .05). In some cases, EGFR immunoexpression was observed without gene amplification. Conclusions: Ameloblastoma development, progression, or recurrence does not appear to be related to EGFR amplification or polysomy. |
| Subject: | Genes Ameloblastoma Proteins |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.oooo.2018.02.014 |
| URI: | http://hdl.handle.net/1843/60449 |
| Issue Date: | May-2018 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S2212440318300853?via%3Dihub |
| metadata.dc.relation.ispartof: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology |
| Appears in Collections: | Artigo de Periódico |
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