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http://hdl.handle.net/1843/60526| Tipo: | Artigo de Periódico |
| Título: | Clinicopathological analysis of head and neck rhabdomyosarcoma: a series of 10 cases and literature review |
| Autor(es): | Flávia Sirotheau Corrêa Pontes Jonas Ikikame de Oliveira Lucas Lacerda de Souza Oslei Paes de Almeida Eduardo Rodrigues Fregnani Rafael Sarlo Vilela Wanessa Miranda-Silva Felipe Paiva Fonseca Hélder Antônio Rebelo Pontes |
| Resumo: | Background To describe the clinicopathological characteristics of a series of head and neck rhabdomyosarcoma (RMS) and to review the literature. Material and Methods Cases diagnosed as RMS affecting the head and neck region were retrospectively retrieved from the files of two Brazilian institutions from January 2006 to January 2017. Data on clinical features (sex, age and affected site), microscopic subtype, immunohistochemical results, treatment employed and follow-up status were obtained from the patient’s medical charts. Results During the period considered, 10 cases of RMS were identified. Females predominated (4M:6F), the mean age at diagnosis was 16.5 years-old and the orbit was the most affected site (4 cases). Microscopically, most cases were classified as embryonal RMS (6 cases) and the Desmin/Myogenin/Myo-D1 immunohistochemical positivity was useful to confirm the diagnosis. Chemotherapy and radiotherapy were applied to 9 and 8 patients respectively, whereas 2 patients were treated by surgery. Recurrences occurred in 3 patients and distant metastasis in 2 cases. Nine patients were alive in their last follow-up, 3 of them with disease, whereas 1 patient died due to the disease. Conclusions Head and neck RMS is an aggressive malignant neoplasm which demands especial concern to achieve early diagnosis and successful treatment. |
| Assunto: | Rhabdomyosarcoma Head Neck Mouth Drug therapy Neoplasms Medical records |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | FAO - DEPARTAMENTO DE CLÍNICA |
| Tipo de Acesso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.4317%2Fmedoral.22106 |
| URI: | http://hdl.handle.net/1843/60526 |
| Data do documento: | 25-Fev-2018 |
| metadata.dc.url.externa: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911360/ |
| metadata.dc.relation.ispartof: | Medicina Oral Patologia Oral y Cirugia Bucal |
| Aparece nas coleções: | Artigo de Periódico |
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| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Clinicopathological analysis of head and neck rhabdomyosarcoma a series of 10 cases and literature review.pdf | 2.75 MB | Adobe PDF | Visualizar/Abrir |
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