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http://hdl.handle.net/1843/60529| Tipo: | Artigo de Periódico |
| Título: | Accuracy of Diagnostic Tests for the Detection of Chagas Disease: A Systematic Review and Meta-Analysis |
| Autor(es): | Mayron Antonio Candia-puma Laura Yesenia Machaca-luque Brychs Milagros Roque-pumahuanca Alexsandro Sobreira Galdino Rodolfo Cordeiro Giunchetti Eduardo Antonio Ferraz Coelho Miguel Angel Chávez Fumagalli |
| Resumo: | The present systematic review and meta-analysis about the accuracy of diagnostic tests aim to describe the findings of literature over the last thirty years for the diagnosis of Chagas disease (CD). This work aimed to determine the accuracy of diagnostic techniques for CD in the disease’s acute and chronic phases. The PubMed database was searched for studies published between 1990 and 2021 on CD diagnostics. Fifty-six published studies that met the criteria were analyzed and included in the meta-analysis, evaluating diagnostic accuracy through sensitivity and specificity. For Enzyme-Linked Immunosorbent Assay (ELISA), Fluorescent Antibody Technique (IFAT), Hemagglutination Test (HmT), Polymerase Chain Reaction (PCR), and Real-Time Polymerase Chain Reaction (qPCR) diagnosis methods, the sensitivity had a median of 99.0%, 78.0%, 75.0%, 76.0%, and 94.0%, respectively; while specificity presented a median of 99.0%, 99.0%, 99.0%, 98.0%, and 98.0%, respectively. This meta-analysis showed that ELISA and qPCR techniques had a higher performance compared to other methods of diagnosing CD in the chronic and acute phases, respectively. It was concluded utilizing the Area Under the Curve restricted to the false positive rates (AUCFPR), that the ELISA diagnostic test presents the highest performance in diagnosing acute and chronic CD, compared to serological and molecular tests. Future studies focusing on new CD diagnostics approaches should be targeted. |
| Assunto: | Imunologia Medicina Sensibilidade e Especificidade Revisão Sistemática Metanálise Doença de Chagas Testes Diagnósticos de Rotina |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | ICB - DEPARTAMENTO DE MORFOLOGIA ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS |
| Tipo de Acesso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.3390/diagnostics12112752 |
| URI: | http://hdl.handle.net/1843/60529 |
| Data do documento: | 10-Nov-2022 |
| metadata.dc.url.externa: | https://www.mdpi.com/2075-4418/12/11/2752 |
| metadata.dc.relation.ispartof: | Diagnostics |
| Aparece nas coleções: | Artigo de Periódico |
Arquivos associados a este item:
| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Accuracy of Diagnostic Tests for the Detection of Chagas Disease_ A Systematic Review and Meta-Analysis (1).pdf | 832.57 kB | Adobe PDF | Visualizar/Abrir |
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