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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60529
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dc.creatorMayron Antonio Candia-pumapt_BR
dc.creatorLaura Yesenia Machaca-luquept_BR
dc.creatorBrychs Milagros Roque-pumahuancapt_BR
dc.creatorAlexsandro Sobreira Galdinopt_BR
dc.creatorRodolfo Cordeiro Giunchettipt_BR
dc.creatorEduardo Antonio Ferraz Coelhopt_BR
dc.creatorMiguel Angel Chávez Fumagallipt_BR
dc.date.accessioned2023-11-06T20:47:53Z-
dc.date.available2023-11-06T20:47:53Z-
dc.date.issued2022-11-10-
dc.citation.volume12pt_BR
dc.citation.issue11pt_BR
dc.citation.spage2752pt_BR
dc.citation.epage20pt_BR
dc.identifier.doihttps://doi.org/10.3390/diagnostics12112752pt_BR
dc.identifier.issn2075-4418pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60529-
dc.description.resumoThe present systematic review and meta-analysis about the accuracy of diagnostic tests aim to describe the findings of literature over the last thirty years for the diagnosis of Chagas disease (CD). This work aimed to determine the accuracy of diagnostic techniques for CD in the disease’s acute and chronic phases. The PubMed database was searched for studies published between 1990 and 2021 on CD diagnostics. Fifty-six published studies that met the criteria were analyzed and included in the meta-analysis, evaluating diagnostic accuracy through sensitivity and specificity. For Enzyme-Linked Immunosorbent Assay (ELISA), Fluorescent Antibody Technique (IFAT), Hemagglutination Test (HmT), Polymerase Chain Reaction (PCR), and Real-Time Polymerase Chain Reaction (qPCR) diagnosis methods, the sensitivity had a median of 99.0%, 78.0%, 75.0%, 76.0%, and 94.0%, respectively; while specificity presented a median of 99.0%, 99.0%, 99.0%, 98.0%, and 98.0%, respectively. This meta-analysis showed that ELISA and qPCR techniques had a higher performance compared to other methods of diagnosing CD in the chronic and acute phases, respectively. It was concluded utilizing the Area Under the Curve restricted to the false positive rates (AUCFPR), that the ELISA diagnostic test presents the highest performance in diagnosing acute and chronic CD, compared to serological and molecular tests. Future studies focusing on new CD diagnostics approaches should be targeted.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofDiagnosticspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectDiagnostic testspt_BR
dc.subjectChagas diseasept_BR
dc.subjectMeta-analysispt_BR
dc.subjectSystematic reviewpt_BR
dc.subjectSensitivitypt_BR
dc.subjectSpecificitypt_BR
dc.subject.otherImunologiapt_BR
dc.subject.otherMedicinapt_BR
dc.subject.otherSensibilidade e Especificidadept_BR
dc.subject.otherRevisão Sistemáticapt_BR
dc.subject.otherMetanálisept_BR
dc.subject.otherDoença de Chagaspt_BR
dc.subject.otherTestes Diagnósticos de Rotinapt_BR
dc.titleAccuracy of Diagnostic Tests for the Detection of Chagas Disease: A Systematic Review and Meta-Analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.mdpi.com/2075-4418/12/11/2752pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6328-3840pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8890-3030pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4181-7546pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6681-9014pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8394-4802pt_BR
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