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http://hdl.handle.net/1843/60548| Type: | Artigo de Periódico |
| Title: | Inulin prebiotic dietary supplementation improves metabolic parameters by reducing the Toll-like receptor 4 transmembrane protein gene and interleukin 6 expression in adipose tissue |
| Authors: | Carla Dayana Durães Abreu Bruna Viana Caldas Guilherme Henrique Mendes Ribeiro Charles Martins Aguilar Lucyana Conceição Farias André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Maria Beatriz Abreu Glória Sérgio Henrique Sousa Santos |
| Abstract: | Background: Lifestyle modifications have increased the consumption of ultra-processed foods, fat, sugar, and salt worldwide and also decreased dietary fiber due to reduced legume, grain, and vegetable intake. Ultimately, the contemporary food intake profile has increased the incidence of obesity and chronic inflammatory diseases. Probiotic dietary supplementation is a viable health option. Methods: Male Swiss mice were fed with two diets for four weeks: standard and standard +Inulin. The serum biochemistry data, histology, and inflammatory-related genes’ mRNA expression in adipose tissue were analyzed. Results: The primary results showed that inulin dietary supplementation decreased the Toll-like receptor 4 transmembrane protein gene (TLR4) expression and interleukin 6 (IL6) in the epididymal adipose tissue, resulting in decreased adipocyte hypertrophy. The high-density lipoprotein (HDL) was increased and TGP enzymes (related to liver injury risk) were decreased also improving insulin sensitivity. Conclusion: The present study revealed that inulin supplementation could improve the onset of chronic inflammation-related markers in adipose tissue indicating that inulin is a natural anti-inflammatory alternative. Data Availability Statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. |
| Subject: | Prebióticos Nutrição Tecido adiposo Inflamação Síndrome metabólica |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.phanu.2022.100316 |
| URI: | http://hdl.handle.net/1843/60548 |
| Issue Date: | 2022 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S2213434422000299 |
| Appears in Collections: | Artigo de Periódico |
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