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http://hdl.handle.net/1843/60709| Type: | Artigo de Periódico |
| Title: | Natural and artificial knitted fabrics functionalized with Cordia curassavica accelerate excisional wound healing in mice |
| Authors: | Janaina Ribeiro Oliveira André Luiz Senna Guimarães Lucyana Conceição Farias Fernanda Steffens Fernando Ribeiro Oliveira Sergio Henrique Sousa Santos Amanda Souto Machado Deborah de Farias Lelis Victor Hugo Dantas Guimarães Luis Paulo Oliveira Sidnei Tavares Reis Theles Oliveira Costa Claudia Regina Vieira Alfredo Mauricio Batista de Paula |
| Abstract: | The present study evaluated the efects of natural and artifcial knitted fabrics functionalized with Cordia curassavica (Jacq.) Roem. & Schult., Boraginaceae, in the skin wound healing process induced in mice. C57BL/6 male mouse wounds were treated as follows: polylactic acid fber; polylactic acid fber + C. curassavica oil; cotton; and cotton + C. curassavica oil. The wound closure kinetics, histological analysis, and fbronectin mRNA expression were evaluated after 3, 5, 7, and 14 days of treatment. The wound closure kinetics area under the curve analysis evidenced the polylactic acid fber + oil treatment accelerating the wound closure as compared to other groups (cotton: 541.7 ± 37.73; cotton + oil: 720.4 ± 27.88; polylactic acid fber: 536.8 ± 33.89; polylactic acid fber + oil: 945.7 ± 33.52). The skin wounds treated with functionalized fabrics showed a proper wound healing resolution, normal granulation tissue architecture and cell infltrate, a lower number of mastocytes, a higher collagen deposition, and increased fbronectin mRNA expression levels. In summary, we report for the frst time that the polylactic acid fber accelerates the wound healing process, an efect potentialized by the C. curassavica volatile oil. These fndings point to the polylactic acid fber + oil as an important alternative therapeutic approach to improve wound healing treatment. |
| Subject: | Cicatrização de feridas Cura Matéria médica vegetal Plantas medicinais |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1007/s43450-021-00225-7 |
| URI: | http://hdl.handle.net/1843/60709 |
| Issue Date: | 2022 |
| metadata.dc.url.externa: | https://link.springer.com/article/10.1007/s43450-021-00225-7 |
| metadata.dc.relation.ispartof: | Revista Brasileira de Farmacognosia |
| Appears in Collections: | Artigo de Periódico |
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