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Type: Artigo de Periódico
Title: Natural and artificial knitted fabrics functionalized with Cordia curassavica accelerate excisional wound healing in mice
Authors: Janaina Ribeiro Oliveira
André Luiz Senna Guimarães
Lucyana Conceição Farias
Fernanda Steffens
Fernando Ribeiro Oliveira
Sergio Henrique Sousa Santos
Amanda Souto Machado
Deborah de Farias Lelis
Victor Hugo Dantas Guimarães
Luis Paulo Oliveira
Sidnei Tavares Reis
Theles Oliveira Costa
Claudia Regina Vieira
Alfredo Mauricio Batista de Paula
Abstract: The present study evaluated the efects of natural and artifcial knitted fabrics functionalized with Cordia curassavica (Jacq.) Roem. & Schult., Boraginaceae, in the skin wound healing process induced in mice. C57BL/6 male mouse wounds were treated as follows: polylactic acid fber; polylactic acid fber + C. curassavica oil; cotton; and cotton + C. curassavica oil. The wound closure kinetics, histological analysis, and fbronectin mRNA expression were evaluated after 3, 5, 7, and 14 days of treatment. The wound closure kinetics area under the curve analysis evidenced the polylactic acid fber + oil treatment accelerating the wound closure as compared to other groups (cotton: 541.7 ± 37.73; cotton + oil: 720.4 ± 27.88; polylactic acid fber: 536.8 ± 33.89; polylactic acid fber + oil: 945.7 ± 33.52). The skin wounds treated with functionalized fabrics showed a proper wound healing resolution, normal granulation tissue architecture and cell infltrate, a lower number of mastocytes, a higher collagen deposition, and increased fbronectin mRNA expression levels. In summary, we report for the frst time that the polylactic acid fber accelerates the wound healing process, an efect potentialized by the C. curassavica volatile oil. These fndings point to the polylactic acid fber + oil as an important alternative therapeutic approach to improve wound healing treatment.
Subject: Cicatrização de feridas
Matéria médica vegetal
Plantas medicinais
language: eng Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights: Acesso Restrito
Issue Date: 2022
metadata.dc.relation.ispartof: Revista Brasileira de Farmacognosia
Appears in Collections:Artigo de Periódico

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