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http://hdl.handle.net/1843/61075| Type: | Artigo de Periódico |
| Title: | Plasma levels of brain-derived neurotrophic factor are associated with prognosis in the acute phase of ischemic stroke |
| Other Titles: | Níveis plasmáticos de fator neurotrófico derivado do cérebro estão associados ao prognóstico na fase aguda do acidente vascular cerebral isquêmico |
| Authors: | Aline Mansueto Mourão Antônio Lucio Teixeira Laélia Cristina Caseiro Vicente Mery Natali Silva Abreu Leonardo Cruz de Souza Aline Silva de Miranda Milene Alvarenga Rachid Romeu Vale Sant'Anna Erica Leandro Marciano Vieira |
| Abstract: | Context: Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neuronal survival, differentiation, and maturation. Purpose: To evaluate the levels of BDNF in the acute phase of stroke and their potential association with neurological impairment. Methods: Patients in the acute phase of ischemic stroke were evaluated with the following clinical tools: National Institutes of Health Stroke Scale, modified Rankin scale, Gugging Swallowing Screen and Alberta Stroke Program Early CT Score. Blood samples were collected at 3 different moments of hospital stay. BDNF was measured through enzyme-linked immunosorbent assay. Results: Patients who were discharged after 10 days had worse clinical outcomes and higher levels of BDNF since admission. There was correlation between BDNF levels and clinical parameters. Conclusion: BDNF levels were associated with clinical prognosis in the acute phase of ischemic stroke. |
| Abstract: | Contexto: O fator neurotrófico derivado do cérebro (BDNF) é uma neurotrofina envolvida na sobrevivência, diferenciação e maturação neuronal. Objetivo: Avaliar os níveis de BDNF na fase aguda do acidente vascular cerebral e sua potencial associação com comprometimento neurológico. Métodos: Pacientes na fase aguda do AVC isquêmico foram avaliados com as seguintes ferramentas clínicas: National Institutes of Health Stroke Scale, escala de Rankin modificada, Gugging Swallowing Screen e Alberta Stroke Program Early CT Score. Amostras de sangue foram coletadas em três momentos diferentes da internação. O BDNF foi medido através de ensaio imunoenzimático. Resultados: Pacientes que receberam alta após 10 dias apresentaram piores desfechos clínicos e níveis mais elevados de BDNF desde a admissão. Houve correlação entre os níveis de BDNF e os parâmetros clínicos. Conclusão: Os níveis de BDNF foram associados ao prognóstico clínico na fase aguda do acidente vascular cerebral isquêmico. |
| Subject: | Fator neurotrófico derivado do cérebro Biomarcadores Acidente vascular cerebral Isquemia cerebral Prognóstico |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ENF - DEPARTAMENTO DE ENFERMAGEM APLICADA ICB - DEPARTAMENTO DE MORFOLOGIA MED - DEPARTAMENTO DE FONOAUDIOLOGIA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.013 |
| URI: | http://hdl.handle.net/1843/61075 |
| Issue Date: | 2019 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S1052305718306517?via%3Dihub |
| metadata.dc.relation.ispartof: | Journal of Stroke and Cerebrovascular Diseases |
| Appears in Collections: | Artigo de Periódico |
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