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http://hdl.handle.net/1843/61083
Type: | Artigo de Periódico |
Title: | Glucose, urea, and creatinine laboratory tests in people starting antiretroviral therapy with dolutegravir or efavirenz: a cohort study in Belo Horizonte, Brazil |
Other Titles: | Exames laboratoriais de glicose, ureia e creatinina em pessoas iniciando a terapia antirretroviral com dolutegravir ou efavirenz: estudo de coorte em Belo Horizonte, Brasil Pruebas de laboratorio de glucosa, urea y creatinina en personas que inician terapia antirretroviral con dolutegravir o efavirenz: un estudio de cohorte en Belo Horizonte, Brasil |
Authors: | Jorgino Julio Cesar Micheline Rosa Silveira Cléssius Ribeiro de Souza Henrique Pereira de Aguilar Penido Ana Cristina da Silva Fernandes do Amaral Maria Das Graças Braga Ceccato |
Abstract: | Objetivo: Monitorar os exames laboratoriais de glicemia, ureia e creatinina em indivíduos virgens de tratamento, iniciando TARV com esquema antirretroviral contendo EFV ou DTG, buscando contribuir para o entendimento da segurança desses medicamentos em uso no mundo real, acompanhados por 72 semanas. Metodologia: Estudo de coorte, com o acompanhamento de pessoas que vivem com HIV e iniciando terapia antirretroviral. Resultados: No grupo que usou dolutegravir, verificou-se aumento nos níveis de creatinina sanguínea em 24 e 48 semanas e glicose em 48 semanas (p=0,017). Naqueles que usaram efavirenz, verificou-se aumento nos níveis de creatinina em 48 semanas (p= 0,007), glicose em 72 semanas (p=0,009) e ureia 48 semanas (p=0,023). Pertencer ao gênero masculino (p=0,044) e apresentar mais que 13 anos de escolaridade (0,044) explicaram a alteração da creatinina. Uso de tabaco (p=0,006), uso de drogas ilícitas (p=0,009) e escolaridade maior ou igual a 13 anos de estudo (p=0,038) foram independentemente associados com as alterações nos níveis de ureia. O esquema terapêutico com efavirenz (OR = 8,20; 95% CI = 1,32-51,05; p=0,024) e escolaridade maior ou igual a 13 anos foram independentemente associados com o aumento na concentração de glicose. Conclusões: O esquema com DTG teve associação com o aumento na creatinina sérica por até 42 semanas, sendo transitório e retornando aos patamares observados antes do início da TARV. O esquema com efavirenz demonstrou estar relacionado com elevação nos níveis de glicose sérica, sendo preferencial a terapia com dolutegravir. |
Abstract: | Goal: In this study, we aimed to monitor the blood glucose, urea, and creatinine laboratory tests in treatment-naive individuals, initiating ART with an antiretroviral regimen containing EFV or DTG, searching for a contribution to the understanding of the safety of these drugs in use in the real world, followed up for 72 weeks. Methods: Cohort study with a follow-up of people living with HIV initiating antiretroviral therapy. Results: An increase in blood creatinine levels at 24 and 48 weeks and blood glucose levels at 48 weeks (p=0.017) was observed in the group using Dolutegravir. Those using Efavirenz evidenced an increase in creatinine levels at 48 weeks (p=0.007), blood glucose levels at 72 weeks (p=0.009), and urea levels at 48 weeks (p=0.023). Being male (p=0.044) and having more than 13 schooling years (0.044) explained the change in creatinine levels. Tobacco use (p=0.006), illicit drug use (p=0.009), and schooling greater than or equal to 13 study years (p=0.038) were independently associated with changes in urea levels. The therapeutic regimen with Efavirenz (OR=8.20; 95% CI=1.32-51.05; p=0.024) and schooling greater than or equal to 13 study years were independently associated with increased blood glucose concentration. Conclusions: The DTG regimen was associated with increased serum creatinine levels for up to 42 weeks and was transient and returning to the levels observed before the start of ART. The Efavirenz regimen was related to increased serum glucose levels, and the Dolutegravir therapy was the preferred regimen. |
Subject: | HIV Antirretrovirais |
language: | por |
metadata.dc.publisher.country: | Brasil |
Publisher: | Universidade Federal de Minas Gerais |
Publisher Initials: | UFMG |
metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE FARMÁCIA SOCIAL FARMACIA - FACULDADE DE FARMACIA |
Rights: | Acesso Aberto |
metadata.dc.identifier.doi: | https://doi.org/10.33448/rsd-v11i5.28541 |
URI: | http://hdl.handle.net/1843/61083 |
Issue Date: | 12-Apr-2022 |
metadata.dc.url.externa: | https://rsdjournal.org/index.php/rsd/article/view/28541 |
metadata.dc.relation.ispartof: | Research, Society and Development |
Appears in Collections: | Artigo de Periódico |
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File | Description | Size | Format | |
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Glucose, urea, and creatinine laboratory tests in people starting antiretroviral therapy with dolutegravir or efavirenz_ a cohort study in Belo Horizonte, Brazil.pdf | 377.84 kB | Adobe PDF | View/Open |
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