Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/61215
Tipo: Artigo de Periódico
Título: Role of salivary transcriptomics as potential biomarkers in oral cancer: a systematic review
Autor(es): Shankargouda Patil
Gururaj Arakeri
Abdul Wahab Alamir
Kamran Habib Awan
Hosam Baeshen
Marco Ferrari
Shekar Patil
Felipe Paiva Fonseca
Peter Brennan
Resumo: Introduction: Transcriptomes in saliva can be used as potential biomarkers for both diagnostic and response to treatment in oral squamous cell carcinoma (OSCC). In this review, we explored their application in this increasingly common disease. Materials and methods: PubMed, EMBASE, Scopus, Web of Science and grey literature from January 1990 to May 2017 were searched. Two independent reviewers performed the study selection according to eligibility criteria. Results: A total of nine studies were included. Three studies showed increased expression of DUSP1, IL8, IL1B, OAZ1, SAT1, S100P and two showed increased expression of miRNA-31 among study groups compared to normal healthy controls. The sensitivity ranged from 14% to 100%, while the specificity ranged from 38% to 100%. miRNA-27b had the highest AUC (write in full) of 0.9643 and DUSP1 had the minimum AUC of 0.41. Conclusion: Salivary transcriptomics may play an effective role as a robust and non-invasive biomarker sighting tool for the diagnosis and management of OSCC.
Assunto: RNA
Biomarkers
Saliva
Systematic review
Carcinoma
Diagnosis
Therapeutics
Idioma: por
País: Brasil
Editor: Universidade Federal de Minas Gerais
Sigla da Instituição: UFMG
Departamento: FAO - DEPARTAMENTO DE CLÍNICA
Tipo de Acesso: Acesso Restrito
Identificador DOI: https://doi.org/10.1111/jop.12895
URI: http://hdl.handle.net/1843/61215
Data do documento: 2019
metadata.dc.url.externa: https://onlinelibrary.wiley.com/doi/10.1111/jop.12895
metadata.dc.relation.ispartof: Journal of Oral Pathology & Medicine
Aparece nas coleções:Artigo de Periódico

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