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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61215
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dc.creatorShankargouda Patilpt_BR
dc.creatorGururaj Arakeript_BR
dc.creatorAbdul Wahab Alamirpt_BR
dc.creatorKamran Habib Awanpt_BR
dc.creatorHosam Baeshenpt_BR
dc.creatorMarco Ferraript_BR
dc.creatorShekar Patilpt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorPeter Brennanpt_BR
dc.date.accessioned2023-11-21T20:50:19Z-
dc.date.available2023-11-21T20:50:19Z-
dc.date.issued2019-
dc.citation.volumeSpt_BR
dc.citation.issue10pt_BR
dc.citation.spage871pt_BR
dc.citation.epage879pt_BR
dc.identifier.doihttps://doi.org/10.1111/jop.12895pt_BR
dc.identifier.issn09042512pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61215-
dc.description.resumoIntroduction: Transcriptomes in saliva can be used as potential biomarkers for both diagnostic and response to treatment in oral squamous cell carcinoma (OSCC). In this review, we explored their application in this increasingly common disease. Materials and methods: PubMed, EMBASE, Scopus, Web of Science and grey literature from January 1990 to May 2017 were searched. Two independent reviewers performed the study selection according to eligibility criteria. Results: A total of nine studies were included. Three studies showed increased expression of DUSP1, IL8, IL1B, OAZ1, SAT1, S100P and two showed increased expression of miRNA-31 among study groups compared to normal healthy controls. The sensitivity ranged from 14% to 100%, while the specificity ranged from 38% to 100%. miRNA-27b had the highest AUC (write in full) of 0.9643 and DUSP1 had the minimum AUC of 0.41. Conclusion: Salivary transcriptomics may play an effective role as a robust and non-invasive biomarker sighting tool for the diagnosis and management of OSCC.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Oral Pathology & Medicinept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectacesso restrito revista Journal of oral pathology & medicine Role of salivary transcriptomics as potential biomarkers in oral cancer: a systematic review acesso restrito assunto RNA fao clínica busca dia 16 do 10 2023pt_BR
dc.subject.otherRNApt_BR
dc.subject.otherBiomarkerspt_BR
dc.subject.otherSalivapt_BR
dc.subject.otherSystematic reviewpt_BR
dc.subject.otherCarcinomapt_BR
dc.subject.otherDiagnosispt_BR
dc.subject.otherTherapeuticspt_BR
dc.titleRole of salivary transcriptomics as potential biomarkers in oral cancer: a systematic reviewpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12895pt_BR
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