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http://hdl.handle.net/1843/61352| Type: | Artigo de Periódico |
| Title: | Evidence of hypoglycemic, lipid-lowering and hepatoprotective effects of the bixin and bixin: β-CD inclusion compound in high-fat-fed obese mice |
| Authors: | Ana Delia Pinzón García Laura Alejandra Ariza Orellano Marcela Guimarães Takahashi de Lazari Paula Peixoto Campos María Esperanza Cortés Segura Rubén Dario Sinisterra Millán |
| Abstract: | Associations between obesity, diabetes type II, and steatosis have long been recognized. However, a pharmacotherapy that acts in a multifactorial manner controlling the interactions between these conditions is not available. A variety of natural plants, functional fatty acids, and other natural dietary compounds have been used in various anti-obesity products. We investigated the effects of oral administration of an antioxidant carotenoid pigment Bixin and Bixin: β-Cyclodextrin in an obese murine model. C57BL/6 male mice (4–5 weeks) received standard diet (2.18 kcal per 1 g) (CT) and high-fat diet (4.38 kcal per 1 g) (CT/OB, BIX and BIX/βCD) (n = 10 per group). After 16 weeks, the BIX and BIX/βCD were treated by gavage (100 μL day-1) for six weeks, with water (CT and CT/OB groups) and (50 mg kg-1 day-1), Bixin (BIX group) or Bix: β-CD (BIX/βCD). Body weight, Lee's Index, adiposity, CHT, TG, CHT/HDL-c, glucose levels (metabolic markers) and, liver markers (AST and ALT) were determined. All metabolic and liver parameters exhibited down-regulation after oral administration of BIX and BIX/βCD. Particularly relevant was Lee’s Index and adiposity in BIX- and BIX/βCD-treated groups (339.18 g/cm -BIX and 327.58 g/cm -BIX/βCD vs. 360.68 g/cm -CT/OB animals), this finds associated with the insulin sensitivity test, showed a clear association between reduction of adipose tissue and decrease of peripherical insulin resistant. In conclusion, our study suggested that the oral administration of the Bixin and Bix: β-CD inclusion compound improved the metabolic parameters evaluate in obese mice, being more palatable and hepatoprotective. |
| Subject: | Carotenoides Diabetes Obesidade - Tratamento Degeneração gordurosa Agentes hipoglicemicos Hipolipemiantes Matéria médica vegetal Ciclodextrinas |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA ICB - DEPARTAMENTO DE PATOLOGIA ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.biopha.2018.06.144 |
| URI: | http://hdl.handle.net/1843/61352 |
| Issue Date: | Oct-2018 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0753332218309703 |
| metadata.dc.relation.ispartof: | Biomedicine & Pharmacotherapy |
| Appears in Collections: | Artigo de Periódico |
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