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http://hdl.handle.net/1843/61359| Type: | Artigo de Periódico |
| Title: | Guaiacol/β-cyclodextrin for rapid healing of dry socket: antibacterial activity, cytotoxicity, and bone repair-an animal study |
| Authors: | Patricia Verónica Aulestia Viera Sávio Morato Lacerda Gontijo Alinne Damásia Martins Gomes Rubén Dario Sinisterra Millán Rodney Garcia Rocha María Esperanza Cortés Segura Marinilce Fagundes dos Santos Maria Aparecida Borsatti |
| Abstract: | Purpose: Dry socket (DS) is one the most common and symptomatic post-extraction complications; however, no consensus on its treatment has been reached. This study aimed to develop a novel dressing material for DS containing the phenolic agent guaiacol and evaluate its biological properties. Methods: An inclusion complex of guaiacol and β-cyclodextrin (Gu/βcd) was prepared by freeze-drying. Its antibacterial activity over six oral bacteria was analyzed using the microdilution method, and its cytotoxicity in osteoblasts was assessed with the MTT assay. The alveolar healing process induced by Gu/βcd was evaluated histologically after the treatment of DS in rats. Results: βcd complexation potentiated Gu’s antibacterial effect and reduced its cytotoxicity in osteoblasts. Bone trabeculae were formed in the alveolar apices of rats treated with Gu/βcd by day 7. On day 14, woven bone occupied the apical and middle thirds of the sockets; on day 21, the entire alveolus was filled by newly formed bone, which was in a more advanced stage of repair than the positive control (Alvogyl™). Conclusion: The improvement in Gu’s biological properties in vitro and the rapid alveolar repair in comparison with Alvogyl™ in vivo demonstrated the benefits of the Gu/βcd complex as a future alternative for the treatment of DS. |
| Subject: | Ciclodextrinas Cicatrização de feridas Agentes antibacterianos Boca - Cirurgia Ossos - Regeneração Alveolite Secagem por congelação |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1007/s10006-019-00747-4 |
| URI: | http://hdl.handle.net/1843/61359 |
| Issue Date: | 2019 |
| metadata.dc.url.externa: | https://link.springer.com/article/10.1007/s10006-019-00747-4 |
| metadata.dc.relation.ispartof: | Oral and Maxillofacial Surgery |
| Appears in Collections: | Artigo de Periódico |
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