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http://hdl.handle.net/1843/61559| Tipo: | Artigo de Periódico |
| Título: | Functionalization of poly(lactic-co-glycolic acid) nanofibrous membranes with antibiofilm compounds |
| Autor(es): | Thaise Cristina Geremias Marcos Antônio Batistella Ricardo de Souza Magini Selene Maria de Arruda Guelli Ulson de Souza Vitorio Franco Luiz Cláudio de Almeida Barbosa Ulisses Alves Pereira Juan Paulo Hinestroza Andrea de Lima Pimenta Antônio Augusto Ulson de Souza |
| Resumo: | The aim of this research was to investigate the activity of functionalized PLGA electrospun membranes in preventing Streptococcus mutans biofilm formation. PLGA nanofibres were functionalized with the additives Melaleuca alternifolia and Coffea canephora essential oils, furan-2(5H)-one, and a novel synthetic butyrolactam, in three concentrations (0.002%, 0.004%, and 0.008% w/v). Samples were characterized by SEM, FTIR-ATR, and GC–MS and exposed to S. mutans cultures. Planktonic growth was determined following a 24- and 48-h incubation period by spectrophotometry and the biofilm formation was evaluated by counting colony forming units. Cytotoxicity of the new biomaterials was assessed by MTS assay, through the quantification of viable placenta-derived stem cells grown over the functionalized nanofibrous membranes. Observation of the electrospun membranes on SEM images revealed the smooth and bead-free morphology of the nanofibres. No solvent residues were observed by FTIR-ATR, but the GC–MS results showed that N,N-dimethylformamide and dimethylsulfoxide were present as residues in the membranes after functionalization. Functionalization reduced bacterial attachment to membrane surfaces, with best results being obtained for M. alternifolia essential oil, furanone, and butyrolactam. Cytotoxicity results showed that furan-2(5H)-one-functionalized membranes demonstrated no statistically significant difference in the cell viability compared to the control membranes. |
| Assunto: | Lactamas Biofilme Streptococcus mutans Essências e óleos essenciais |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS ICX - DEPARTAMENTO DE QUÍMICA |
| Tipo de Acesso: | Acesso Restrito |
| Identificador DOI: | https://doi.org/10.1002/cjce.24115 |
| URI: | http://hdl.handle.net/1843/61559 |
| Data do documento: | 16-Mar-2021 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/full/10.1002/cjce.24115 |
| metadata.dc.relation.ispartof: | The Canadian Journal of Chemical Engineering |
| Aparece nas coleções: | Artigo de Periódico |
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