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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61559
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dc.creatorThaise Cristina Geremiaspt_BR
dc.creatorMarcos Antônio Batistellapt_BR
dc.creatorRicardo de Souza Maginipt_BR
dc.creatorSelene Maria de Arruda Guelli Ulson de Souzapt_BR
dc.creatorVitorio Francopt_BR
dc.creatorLuiz Cláudio de Almeida Barbosapt_BR
dc.creatorUlisses Alves Pereirapt_BR
dc.creatorJuan Paulo Hinestrozapt_BR
dc.creatorAndrea de Lima Pimentapt_BR
dc.creatorAntônio Augusto Ulson de Souzapt_BR
dc.date.accessioned2023-11-30T15:30:40Z-
dc.date.available2023-11-30T15:30:40Z-
dc.date.issued2021-03-16-
dc.citation.volume100pt_BR
dc.citation.issueS1pt_BR
dc.citation.spageS5pt_BR
dc.citation.epageS15pt_BR
dc.identifier.doihttps://doi.org/10.1002/cjce.24115pt_BR
dc.identifier.issn1939-019Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61559-
dc.description.resumoThe aim of this research was to investigate the activity of functionalized PLGA electrospun membranes in preventing Streptococcus mutans biofilm formation. PLGA nanofibres were functionalized with the additives Melaleuca alternifolia and Coffea canephora essential oils, furan-2(5H)-one, and a novel synthetic butyrolactam, in three concentrations (0.002%, 0.004%, and 0.008% w/v). Samples were characterized by SEM, FTIR-ATR, and GC–MS and exposed to S. mutans cultures. Planktonic growth was determined following a 24- and 48-h incubation period by spectrophotometry and the biofilm formation was evaluated by counting colony forming units. Cytotoxicity of the new biomaterials was assessed by MTS assay, through the quantification of viable placenta-derived stem cells grown over the functionalized nanofibrous membranes. Observation of the electrospun membranes on SEM images revealed the smooth and bead-free morphology of the nanofibres. No solvent residues were observed by FTIR-ATR, but the GC–MS results showed that N,N-dimethylformamide and dimethylsulfoxide were present as residues in the membranes after functionalization. Functionalization reduced bacterial attachment to membrane surfaces, with best results being obtained for M. alternifolia essential oil, furanone, and butyrolactam. Cytotoxicity results showed that furan-2(5H)-one-functionalized membranes demonstrated no statistically significant difference in the cell viability compared to the control membranes.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofThe Canadian Journal of Chemical Engineering-
dc.rightsAcesso Restritopt_BR
dc.subjectantibiofilme bacterianopt_BR
dc.subjectbacterial adhesionpt_BR
dc.subjectelectrospinningpt_BR
dc.subjectquorum sensingpt_BR
dc.subject.otherLactamaspt_BR
dc.subject.otherBiofilmept_BR
dc.subject.otherStreptococcus mutanspt_BR
dc.subject.otherEssências e óleos essenciaispt_BR
dc.titleFunctionalization of poly(lactic-co-glycolic acid) nanofibrous membranes with antibiofilm compoundspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1002/cjce.24115pt_BR
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